SENSORY BASIS FOR BEHAVIOR IN MOSQUITOES

复杂的集成行为主要是流程的结果 在生物体的中枢神经系统中。然而， 外周感觉系统起着决定性的作用，因为它为 CNS可以在其基础上运行。此外， 外周感觉器官可能决定哪些行为将是 表达。一种似乎受到监管的行为，至少在 部分，通过女性外周受体系统的活动 蚊子是一种寻找宿主的行为--一种直接相关的行为 将疾病传播给人类和他的动物。在 目前的研究，我们一直在进行体液调查 对宿主敏感的受体诱导脱敏 引诱剂，乳酸(LA)，以及随后对宿主的抑制- 在一顿血餐之后寻找行为。我们确定了消息来源 的抑制因子作为脂肪体，并有初步 有证据表明卵巢蜕皮类固醇与 触发抑制物的合成和/或释放。在……里面 此外，我们还假设了一种新的理论来解释 LA兴奋和LA抑制神经元在调制和 本研究拟对寄主寻找行为的控制进行研究。我们 打算将这些调查扩展到下一阶段 血餐后对寻找宿主行为的抑制，特别是 保持对寄主的抑制和恢复 产卵后寻找活动。我们还打算检查 其他受体系统的活性和潜在相互作用 有寻找宿主的行为。 这项研究的最终目标是获得更好的 了解监管和监管的基本机制 控制雌性蚊子的寻找宿主和其他行为。 这里开发的信息应该有助于确定如何 这些机制可以用在一项减少 通过这些重要媒介传播疾病的可能性 有机体。

Complex integrated behavior is primarily the result of processes in the central nervous system of an organism. However, the peripheral sensory system plays a decisive role in that it provides a basis on which the CNS can operate. Furthermore, the peripheral sensory organs may determine which behavior will be expressed. One behavior that appears to be regulated, at least in part, by the activity of a peripheral receptor system in female mosquitoes is host-seeking behavior--a behavior directly related to the transmission of diseases to man and his animals. In the current research, we have been investigating the humorally induced desensitization of the receptors sensitive to the host attractant, lactic acid (LA), and the subsequent inhibition of host- seeking behavior following a blood meal. We identified the source of the inhibitory factor as the fat body and have preliminary evidence that the ovarian ecdysteroids are responsible for triggering the synthesis and/or release of the inhibitor. In addition, we have postulated a new theory for the interaction of the LA-excited and LA-inhibited neurons in the modulation and control of host-seeking behavior in the proposed research. We intend to extend these investigations to the next stage in the post-blood meal inhibition of host-seeking behavior, specifically the maintenance of the inhibition and the recovery of host- seeking activity following oviposition. We also intend to examine the activity and potential interaction of other receptor systems with host-seeking behavior. The ultimate goal in this research is to gain a better understanding of the mechanisms underlying the regulation and control of host-seeking and other behaviors of female mosquitoes. The information developed here should aid in determining how these mechanisms might be employed in a strategy to reduce the potential for disease transmission by these important vector organisms.