TESTING OF ADAPTIVE BONE CHANGE HYPOTHESES

描述：(改编自调查人员摘要)目的 研究是将动物研究中发生的骨骼变化联系起来 与计算出的松质骨中存在的应力模式进行比较。 研究的重点是找到最简单可用的应力--骨 预测总骨量长期变化的密度关系 关节置换、骨折固定装置和截骨术。在……里面 此外，还将进行详细的骨骼历史形态测量，以确定 骨骼变化代表稳定的平衡状态，并提供 关于可以用来更好地开发的生物机制的信息 理论模型。本研究的具体目的是：(1)测量 取材犬股骨的松质骨密度 (2)进行复杂的有限元应力计算。 对股骨进行分析；以及(3)执行以下回归分析 各种应力参数和骨密度。背散射电子 成像和定量骨组织形态计量学将用于表征 松质骨。详细的三维有限元应力分析将 用于确定应力分布。

DESCRIPTION: (Adapted from investigator's abstract) The purpose of this study is to correlate bone changes which have occurred in an animal study with the calculated stress patterns which exist in the cancellous bone. The emphasis of the study is to find the simplest usable stress-bone density relationship which predicts long term bone changes around total joint replacements, fracture fixation devices and osteotomies. In addition, detailed bone histormorphometry will be performed to see if the bone changes represent a stable equilibrium condition and to provide information on biological mechanisms which can be used to develop better theoretical models. The specific aims of this study are to: (1) measure the cancellous bone density throughout retrieved dog femora, both with and without implants in them; (2) perform sophisticated finite element stress analyses of the femora; and (3) perform a regression analysis between various stress parameters and bone density. Back scattered electron imaging and quantitative bone histomorphometry will be used to characterize the cancellous bone. A detailed 3-D finite element stress analysis will be used to determine the stress distributions.