INTESTINAL WALL INVESTIGATION BY AN ENDOSCOPE ECHO PROBE

胃肠道内窥镜检查是一项广泛应用的诊断技术 胃肠病学。新的纤维内窥镜可以检查内部 整个上下胃肠道的衬里和活组织检查 通过内窥镜采集这个粘膜表面的样本。然而，它并不是 可能到达它下面足够深的地方来检查整个厚度 墙或底层结构。尽管新的成像技术 可用(经皮超声、核磁共振等)， 这些技术不能成像肠壁来确定诊断 大多数患者由于分辨率不足，肠壁移动和 无法通过在以下位置确定的局部区域制作横向切片 内窥镜检查。此外，这些技术昂贵、缓慢，而且 可获得性有限。 我们计划研究和开发一种内窥镜微型超声 安装在内窥镜导管顶端的成像系统 通过现有内窥镜的活组织检查通道。因为这个系统 将使用高频(15-20 MHz)，它将产生出色的分辨率 (0.3 mm)肠壁及邻近结构。高分辨率 将以低渗透率为代价获得，但这不是 问题是探头直接放在要成像的组织上。 该设备将易于使用、定向和解释，并具有高分辨率 图像。该设备将相对便宜，因此具有 卓越的成本效益比。 调查将涉及几个步骤，其中第一个步骤是建立 实验室原型机。在解决了设计注意事项之后， 该探头在切除的人体组织和动物的内窥镜中进行了测试 原型将被建造出来。这种装置将在动物身上和其他动物身上进行测试 切除的组织。然后将在患有以下疾病的患者身上进行临床测试 肠壁全厚的疾病。这包括 克罗恩病和胃、食道和结肠的肿瘤。它可能 在壁肌的生理学研究中也是有用的。这个设备 将为胃肠道疾病的诊断提供一个新的维度。

Gastrointestinal endoscopy is a widely practiced diagnostic technology in gastroenterology. New fiberendoscopes allow the inspection of the interior lining of the entire upper and lower gastrointestinal tracts and biopsies taken via the endoscope sample this mucosal surface. However, it is not possible to reach deep enough beneath it to examine the full thickness of the wall or the underlying structures. Although new imaging technology is available (percutaneous ultrasound, nuclear magnetic resonance, etc.), these techniques cannot image the intestinal wall to determine a diagnosis in most patients because of insufficient resolution, gut wall movement and inability to make transverse slices through localized areas identified at endoscopy. Furthermore, these techniques are expensive, slow, and of limited availability. We plan to investigate and develop an endoscopic miniature ultrasound imaging system mounted onto the tip of an endoscopic catheter which can be passed via the biopsy channel of available endoscopes. Because this system will use high frequency (15-20 MHz), it will yield excellent resolution (0.3mm) of the gut wall and the adjacent structures. The high resolution will be obtained at the expense of low penetration but this is not a problem because the probe is placed directly on the tissue to be imaged. The device will be easy to use, orient and interpret, with high resolution images. The device will be relatively inexpensive and therefore has an excellent cost benefit ratio. The investigation will involve several steps of which the first is to build a laboratory prototype. After the design considerations are resolved and the probe is tested in excised human tissue and in animals, an endoscopic prototype will be built. This device will be tested in animals and on excised tissue. It will then undergo clinical testing in patients with disease involving the full thickness of the intestinal wall. This includes Crohn's disease and neoplasms of the stomach, esophagus and colon. It may also be useful in physiologic studies of the wall musculature. This device will provide a new dimension in the diagnosis of gastrointestinal disease.