Engineering the trafficking of nanoparticles within cells

该项目旨在设计能够在细胞内高效运输的响应性纳米颗粒。治疗货物的释放地点对于提高许多治疗的疗效具有重要意义，例如疫苗输送。因此，有必要从根本上理解如何设计纳米颗粒结构来控制细胞行为。该项目将设计新的聚合物纳米材料，并研究其结构对生物特性的影响。该项目的好处将包括对改进疫苗输送纳米颗粒设计的新的基本见解，以及扩大澳大利亚在可生物降解聚合物领域的知识库。

This project aims to engineer responsive nanoparticles capable of trafficking efficiently within cells. The site of release of therapeutic cargo has importance for improving the efficacy of many treatments, for example vaccine delivery. Therefore fundamental understanding of how nanoparticle structure can be engineered to control cellular behaviour is necessary. The project will engineer new polymeric nanomaterials and investigate the impact of their structure on biological properties. The benefits of this project will include new fundamental insights into improving nanoparticle design for vaccine delivery, as well as the expansion of Australia’s knowledge base in the area of biodegradable polymers.