ANALYSIS OF MONONUCLEAR PHAGOCYTE DIFFERENTIATION

这项研究项目主要涉及分析巨噬细胞 通过一系列鼠肿瘤细胞系的研究， 其显示不同程度的成熟停滞。 许多同种异体抗原和 杂交瘤定义的细胞表面组分变得可用于 进一步定义巨噬细胞谱系的细胞亚群，和 这些组分将用于分化停滞的一般研究， 肿瘤内异质性，以及进一步诱导 这些细胞系的分化。 特别强调 功能特性（抗原呈递，杀肿瘤活性， 吞噬作用）及其与细胞表面表型标记物的相关性， 在特定的分化阶段由单克隆抗体定义。 （MB）

This research project essentially involves an analysis of macrophage differentiation through a study of a series of murine tumor cell lines, which show various degrees of maturation arrest. Many alloantigens and hybridoma-defined cell surface components are becoming available for further definition of subpopulations of cells of macrophage lineages, and these components will be used in a general study of differentiation arrest, intratumor heterogeneity, and potential for further induction of differentiation in these cell lines. Particular emphasis is being placed on functional properties (antigen presentation, tumoricidal activity, phagocytosis) and their correlation with cell surface phenotypic markers as defined by monoclonal antibodies at specific differentiation stages. (MB)