课题基金 / 基金详情

TRANSFORMATION BY ABELSON MURINE LEUKEMIA VIRUS

TRANSFORMATION BY ABELSON MURINE LEUKEMIA VIRUS
阿贝尔森鼠白血病病毒的转化
批准号：
3167666
负责人：
OWEN N. WITTE
金额：
$15.66万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
1980
资助国家：
美国
项目状态：
已结题
起止时间：
1980-05-01 至 1991-04-30
来源：
https://reporter.nih.gov/project-details/3167666
关键词：
Abelson leukemia virus Retroviridae disease disease /disorder model gene expression genetic manipulation genetic regulation helper virus laboratory mouse laboratory rabbit myelogenous leukemia oncogenic virus radiotracer serology /serodiagnosis surface antigens temperature sensitive mutant tissue /cell culture viral leukemogenesis virus RNA virus genetics virus protein

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中文摘要
翻译
这项提案将研究ABL使用的分子机制 癌基因在其正常和异常生长调节中的作用。两个版本的比较 结构、调节、造血转化活性，以及 小鼠细胞和病毒酪氨酸激酶的酶学性质 ABL基因的形式以及ABL的易位衍生形式 在慢性粒细胞白血病细胞中发现的基因将被执行。 重点将放在建立小鼠转化细胞模型上 ABL或其他癌基因调控下的干细胞群 演唱会与改进的文化技术。这些研究应该有助于我们 对肿瘤发生和造血机制的认识 发展。
英文摘要
This proposal will investigate the molecular mechanisms used by the abl oncogene in its normal and abnormal growth regulation. Comparison of the structures, regulation, hematopoietic transformation activities, and tyrosine kinase enzymatic properties of the murine cellular, and viral forms of the abl gene as well as the translocation derived form of the abl gene found in Chronic Myelogenous Leukemia cells will be performed. Emphasis will be placed on establishing transformed cell models for murine stem cell populations under the regulation of abl or other oncogenes in concert with improved culture techniques. These studies should aid our understanding of the mechanisms of oncogenesis and hematopoietic development.
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