DIOL EPOXIDE AND OTHER DERIVATIVES OF PAH:SAR'S

多环芳烃（PAH）是普遍存在的组分， 环境，由有机物燃烧产生。 PAH展示 广泛不同的致癌性，并阐明其依据 变异是五十多年来的研究目标。 在过去的十年里，越来越多的证据表明新陈代谢 二醇环氧化物是激活PAH的关键事件， 致癌和致突变的形式。 其中最有效的致癌物质是那些海湾地区的二醇 环氧化物将在环氧化物部分受到空间位阻， 苯并环（峡湾区域）或甲基。 在这项研究中，二醇 致癌物苯并[g]芘的环氧化物和其他衍生物， 合成了 这种碳氢化合物，与海湾和峡湾地区，提供了 表观构效关系的良好测试， 结构上复杂的未取代的PAH二醇环氧化物， 从以前的工作中得到的。 PAH上的甲基取代也很常见， 和甲基化多环芳烃是最致癌的。 通过 二氢衍生物和四氢环氧化物衍生物的制备 角环的各种甲基化苯并[a]蒽，这将是可能的 探测甲基远离时的电子效应， 环氧化物，以及当它接近环氧化物时的空间效应。 将对本工作中合成的化合物进行致突变性试验， 通过合作安排的肿瘤。

Polycyclic aromatic hydrocarbons (PAH) are ubiquitous components of the environment, produced by the combustion of organic matter. PAH exhibit widely varying carcinogenicities, and elucidation of the basis for that variation has been a research goal for over fifty years. Within the past ten years, evidence has been accumulating that metabolism to diol epoxides is the key event in activation of the PAH to ultimate carcinogenic, and mutagenic, forms. Among the most potent carcinogens are those in which a bay region diol epoxide would be sterically hindered at the epoxide moiety, either by a benzo ring (fjord region) or by a methyl group. In this research, diol epoxide and other derivatives of the carcinogen benzo[g]chrysene will be synthesized. This hydrocarbon, with both bay and fjord regions, provides a good test of the apparent structure-activity relation-ships for less structurally complex unsubstituted PAH diol epoxides that have been obtained from previous work. Methyl substitution on PAH is also common, and methylated PAH are among the most carcinogenic. Through the preparation of dihydro derivatives and tetrahydroepoxide derivatives on the angular ring of various methylated benz[a]anthracenes, it will be possible to probe the electronic effect of the methyl group when it is remote from the epoxide, and the steric effect when it is proximate to the epoxide. Compounds synthesized in this work will be tested for mutagenicity and tumorigenicity through collaborative arrangements.