MEDICAL ADRENALECTOMY FOR ADVANCED PROSTATE CANCER

一种有效的药物肾上腺切除术方案已被用来抑制 肾上腺类固醇的合成和雌激素的产生在妇女的治疗 患有晚期乳腺癌 该方案将适用于男性 用于治疗晚期前列腺癌。 用于医疗的方法 肾上腺切除术使用氨鲁米特（AG）与 氢化可的松 AG似乎有两个独立的作用： 类固醇生成和外周芳构化的阻断 雄激素形成雌激素。 “药物肾上腺切除术”方案 似乎等于，如果不是更好，手术肾上腺切除术， 晚期乳腺癌的治疗 目前的研究将提供 有机会详细评估激素的后果和临床 对药物肾上腺切除术治疗男性 播散性前列腺癌 我们预计大量的荷尔蒙 对接受这种主要化学消融的男性人群的研究 治疗将提供有用的信息，以完整的医疗 消融过程以及肿瘤对这种方式的反应， 治疗 我们实验室的初步研究表明， 降低睾丸切除男性血浆中的雄激素和雌激素水平， 前列腺转移癌，并提供鼓励，这是 治疗方式可能是有用的。

An effective medical adrenalectomy regimen has been used to suppress adrenal steroid synthesis and estrogen production in the treatment of women with advanced breast cancer. This regimen will be adapted for use in men for the treatment of advanced prostatic carcinoma. The method for medical adrenalectomy uses aminoglutethimide (AG) in combination with hydrocortisone. AG appears to have two separate actions: inhibition of steroid-ogenesis and the blockade of the peripheral aromatization of androgens to form estrogens. The regimen of "medical adrenalectomy" appears to be equal to, if not better than, surgical adrenalectomy for the treatment of advanced breast cancer. The current study will provide the opportunity to evaluate in detail the hormonal consequences and clinical responses to medical adrenalectomy in the treatment of men with disseminated prostatic carcinoma. We anticipate that extensive hormonal studies of a population of men undergoing this major chemical ablative therapy will provide useful information as to completeness of the medical ablative procedure as well as tumor response to this modality of treatment. Preliminary studies from our laboratory indicates that AG reduces androgen and estrogen levels in plasma of orchiectomized men with metastatic cancer of the prostate and provides encouragement that this modality of therapy may prove to be useful.