IMMUNOGENETICS OF HYBRID RESISTANCE

杂交抗性是阻止H-2移植物的增殖 F1代杂种小鼠的纯合子正常或肿瘤造血细胞 H-2杂合子。 这一观察违反了 移植遗传学，其中指出，组织相容性抗原是 共同显性遗传。 主要杂种或 造血组织相容性（Hh）抗原定位于H-2D。 这里的目标 是为了确定基因是反式还是顺式构型， 调节表达以确定供体细胞的免疫原性， F1代杂种宿主中是否存在杂种抗性。 的 同种异体抑制的可能性，即，寄主识别 同种异体抗原的供体细胞启动反应，将是 研究了最后，对Hh抗原诱导免疫耐受的机制进行了探讨。 将被探索。 这项工作的潜在重要性涉及到 自身免疫和肿瘤免疫监视，因为父母和F1 杂交体共享相同Hh抗原的结构基因。 （斯洛伐克共和国）

Hybrid resistance is the prevention of proliferation of grafts of H-2 homozygous normal or neoplastic hemopoietic cells by F1 hybrid mice heterozygous at H-2. This observation goes against the laws of transplantation genetics, which state that histocompatibility antigens are inherited codominantly. The determinants for the major hybrid or hemopoietic histocompatibility (Hh) antigens map at H-2D. The aims here are to determine if genes in the trans or cis configuration with Hh regulate expression so as to determine immunogenicity of donor cells and presence or absence of hybrid resistance in F1 hybrid hosts. The possibility of allogeneic inhibition, i.e., recognition of host alloantigens by the donor cells to initiate the response, will be investigated. Finally, the mechanism of tolerance induction to Hh antigens will be explored. The potential importance of this work relates to autoimmunity and tumor immune surveillance, since the parent and the F1 hybrid share the structural gene for the same Hh antigen. (SR)