IDIOTYPE VACCINES FOR CANCER PATIENTS

癌症患者的免疫系统通常受到抑制，并试图 免疫疗法都失败了。 我们在此提议， 一种新的癌症患者实验性免疫治疗方法， 基于独特型网络的概念。 根据这一假设， 某些独特位模拟抗原（内部抗原），包括自身和 肿瘤相关抗原。 由于我们最近使用这个概念， 生产一种实验性的独特位疫苗来对抗链球菌感染 在小鼠中，我们将应用相同的策略来生产独特位疫苗， 癌症患者。 治疗性肺炎需要接种链球菌肺炎疫苗。 淋巴增生性恶性肿瘤的治疗方案;然而，现有的疫苗 （Pneumovax）通常是无效的。 我们建议开发一种替代品， 这种疫苗是基于我们在抗链球菌独特型方面的经验 小鼠的疫苗 我们还计划开发针对人B细胞的独特位疫苗 淋巴瘤 这种方法是基于我们的能力， 针对淋巴增生性恶性肿瘤的杂交瘤抗体， 必要的工具，以产生抗独特型表达内部 这些肿瘤的抗原。 最后，我们将提高兼容性和有效性， 以鼠为基础的独特型疫苗， 抗独特型抗体的研究。

The immune system in cancer patients is often suppressed and attempts to apply immunotherapy are met with failure. We are proposing here to develop a new approach of experimental immunotherapy for cancer patients which is based on the idiotype network concept. According to this hypothesis, certain idiotopes mimick antigens (internal antigens), including self and tumor-associated antigens. Since we have recently used this concept to produce an experimental idiotope vaccines against streptococcal infection in mice, we will apply the same strategy to produce idiotope vaccines for cancer patients. Vaccination against streptococcal pneumonia is required in therapeutic protocols for lymphoproliferative malignancies; however existing vaccines (Pneumovax) often is ineffective. We propose to develop a substitute for this vaccine based on our experience with the anti-steptococcal idiotype vaccines in mice. We are also planning to develop an idiotope vaccine against human B cell lymphomas. This approach is based on our ability to produce specific hybridoma antibodies against lymphoproliferative malignancies which provide the necessary tools to generate anti-idiotypes expressing the internal antigens of such tumors. Finally, we will improve the compatibility and the effectiveness of murine-based idiotype vaccines by creating chiemiric mouse-man anti-idiotype antibodies using molecular biology methods.