EFFECTS OF HYPERFRACTIONATED RADIATION ON BONE GROWTH

本研究的主要目的是探讨 分馏和其他潜在的影响因素 辐射诱导的生长骨损伤的表达， 预测将改善治疗指数的方法 儿科恶性肿瘤的治疗。 使用大鼠模型， 将进行实验，以便：更好地定义 超分割辐射方案的组织保护潜力; 阐明分次照射损伤的机制， 观察剂量和分割之间的关系 时间表和各种组织病理学终点;以及研究 剂量、分割、束流能量和 伴随药物治疗对各种组织的修复能力 隔室（软骨细胞，微血管，骨细胞， 矩阵等）。 在这些实验中，组织形态计量学方法， 分析将被利用，以允许定量的组织学 在大量的标本的终点。 发展和 应用形态测量技术测定辐射 这个复杂系统中的剂量-反应关系可能会提供一个 分析辐射诱导正常组织的有用工具 一般的伤害。

The primary goal of this study is to explore the role of fractionation and other potentially influential factors in the expression of radiation-induced damage to growing bone to predict appraoches which would improve therapeutic index in the treatment of pediatric malignancies. Using a rat model, a variety of experiments will be performed in order to: better define the tissue-sparing potential of hyperfractionated radiation schedules; clarify the mechanisms of damage of fractionated irradiation by observing the relationship between dose and fractionation schedule and a variety of histopathological endpoints; and study the influence of dose, fractionation, beam energy and concomitant drug therapy on the repair capacity of various tissue compartments (chondrocytes, microvasculature, osteocytes, matrix, et.). In these experiments, histomorphometric methods of analysis will be exploited to permit quantification of histological endpoints in a large number of specimens. Development and application of morphometric techniques to determine radiation dose-response relationships in this complex system may provide a useful tool for the analysis of radiation-induced normal tissue damage in general.