INTERMEDIATE OUTCOME MARKERS FOR BREAST CANCER

我们计划评估各种中间体之间的关系 乳腺癌患者的预后指标和死亡率 筛选设置。普吉特湾团体健康合作社 作为解决问题的队列方法的独特场所，因为 它服务于40岁和40岁的大量固定人口 年长(68,796人)，有既定的SEER登记以允许 所有病例和死亡的识别，积极的基于风险的乳房 提供风险因素信息的癌症筛查计划 并确保大量接受筛查和未筛查的妇女，以及 允许检索筛查的统一病历系统 病史和详细的手术和病理检查 已定义人口的所有成员的信息。 分析方法(混合病例队列设计)是一种 对Prentice病例队列方法的修改，即 通常比病例对照设计在统计学上更有效 而且比标准的队列设计要便宜得多。重要 在我们的方法中，我们仔细考虑了偏见的来源。

We plan to evaluate the relationship between various intermediate outcome measures and mortality from breast cancer in a screening setting. Group Health Cooperative of Puget Sound serves as a unique site for a cohort approach to the problem, since it serves a large defined population of women 40 years of age and older (68,796), has an established SEER registry to permit identification of all cases and deaths, an active risk-based breast cancer screening program which provides risk factor information and assures large numbers of screened and unscreened women, and a unified medical record system permitting retrieval of screening history and detailed surgical and pathological examination information for all members of the defined population. The analytic approach (hybrid case-cohort design) is a modification of the case-cohort approach of Prentice which is typically more efficient statistically than case-control designs and much less costly than a standard cohort design. Important sources of bias are carefully considered in our approach.