DEVELOPMENT OF A MULTI-CRYSTAL BRAIN SPECT SYSTEM

由于最近商业开发的单光子示踪剂， 功能性脑成像，诊断某些脑部疾病， 临床EGT（发射计算机断层扫描）已经成为现实， 社区医院。 然而，目前可用的单光子 发射计算机断层摄影（SPECT）系统不具有足够的 分辨率和灵敏度，以充分利用这些放射性药物 预付款。 SPECT成像的未来重要性源于其 可负担的成本和其功能成像的潜力不断增加。 SPECT可以建立在庞大的知识库和许多诊断基础上， PET研究开发的技术，以造福公众， 广泛使用的技术。 为了让SPECT承担这一重要的 作用，以高性能为特征的实用成像系统， 特别是高分辨率，将不得不开发。 该研究的目的是开发一种新型的高性能 用于临床脑成像的SPECT系统。 这个SPECT系统的概念 是基于我们以前报道的单片设计，其特点是 旋转准直器组件和固定环形检测器系统。 的 当前的提议将我们的SPECT成像技术扩展到第三维。 这涉及探测器和准直器系统的重新设计， 为脑部成像提供全轴向覆盖。 广泛的初步调查已进行使用这两个 软件模拟和台式实验，以建立 新准直器和探测器配置的可行性。 一 目前正在建造一个桌面原型系统， 我们新设计的性能潜力 下一步是建立 一种成像系统，其对于各种各样的 临床应用。 本提案寻求支持发展和建设一个 原型临床SPECT系统及其相关研究 发展 原型系统的成像性能将是 并在调查中进行了优化。

Due to the recent commercial development of single photon tracers for functional brain imaging, the diagnosis of certain brain disorders with clinical EGT (emission computed tomography) is already a reality in many community hospitals. However, the currently available single photon emission computed tomography (SPECT) systems do not have adequate resolution and sensitivity to fully exploit these radiopharmaceutical advances. The future importance of SPECT Imaging derives from its affordable cost and its increasing potential for functional imaging. SPECT can build on the vast knowledge base and the many diagnostic techniques developed by PET research to benefit the general public with widely accessible techniques. In order for SPECT to assume this important role, practical imaging systems characterized by high performance, specifically high resolution, will have to be developed. The goal of the proposed research is to develop a novel high performance SPECT system for clinical brain imaging. The concept of this SPECT system is based on our previously reported single-slice design, which features a rotating collimator assembly and a stationary ring-detector system. The current proposal extends our SPECT imaging technique to the 3rd dimension. This involves a redesign of the detector and the collimator systems to provide full axial coverage for brain imaging. Extensive preliminary investigations have been performed using both software simulations and bench-top experiments to establish the feasibility of the new collimator and detector configurations. A table-top prototype system is currently being constructed to demonstrate the performance potential of our new designs. The next step is to build an imaging system which is sufficiently versatile for a wide variety of clinical applications. This proposal seeks support for the development and construction of a prototype clinical SPECT system and the research which relates to this development. The imaging performances of the prototype system will be characterized and optimized in the investigation.