A LONGITUDINAL NEUROPSYCHIATRIC COMPARISON OF TWO GROUPS

我们建议进行一项纵向观测研究 男性同性恋者HIV感染的神经精神后遗症 以及异性恋前静脉注射吸毒者。利用一种 纵向重复测量设计，我们将评估60 血清阳性的异性静脉注射吸毒者服用美沙酮 6个月后维持和60名血清呈阳性的男性同性恋者 间隔时间为三年。我们还将关注60 血清阴性的异性静脉注射吸毒者服用美沙酮 维持者和60名血清阴性的男同性恋者作为对照。 受试者将从旧金山现有的两个队列中抽取 综合医院(SFGH)。 结果衡量标准将强调精神症状学， 医学和免疫功能分析和神经心理学和 神经生理学参数。 将定期在这些地区收集数据 在三年的研究期内。 拟议研究的具体目标如下： 1.估计本病的发病率和流行率 HIV患者的神经心理和神经生理功能障碍 抗体阳性的同性恋男性和曾经静脉注射海洛因 用户，并确定是否存在组间差异。 2.描述神经心理学和神经心理学的自然历史 三年随访期内的神经生理功能障碍。 3.考察神经心理、心理、心理因素之间的相互关系 神经生理学、精神病学和免疫功能变量。 4.确定神经心理障碍的发生是否 神经生理功能障碍可能被用来预测 特定疾病状态的后续发展 与艾滋病和/或ARC的诊断相关。 5.促进有效筛查的发展 人群神经精神功能障碍测定仪 学习。

We propose to conduct a longitudinal observational study of the neuropsychiatric sequelea of HIV infection in male homosexuals and heterosexual former intravenous drug abusers. Utilizing a longitudinal repeated measures design, we will evaluate 60 seropositive heterosexual intravenous drug abusers on methadone maintenance and 60 seropositive male homosexuals at six month intervals over a three year period. We will also follow 60 seronegative heterosexual intravenous drug abusers on methadone maintenance and 60 seronegative homosexual males as controls. Subjects will be drawn from two existing cohorts at San Francisco General Hospital (SFGH). Outcome measures will emphasize psychiatric symptomatology, medical and immune function analyses and neuropsychological and neurophysiological parameters. Data will be collected in each of these areas at regular intervals over the three year study period. Specific aims of the proposed study are as follows: 1. To estimate the incidence and prevalence of neuropsychological and neurophysiological dysfunction in HIV antibody positive homosexual males and former intravenous heroin users, and to determine whether intergroup differences exist. 2. To describe the natural history of neuropsychological and neurophysiological dysfunction over a three-year follow-up period. 3. To examine the interrelationships among neuropsychological, neurophysiological, psychiatric and immune function variables. 4. To determine whether the occurrence of neuropsychological and neurophysiological dysfunction may be used as a predictor of the subsequent development of particular disease states associated with diagnoses of AIDS and/or ARC. 5. To facilitate the development of an effective screening instrument for neuropsychiatric dysfunction in the populations studied.