BIRTH CHARACTERISTICS AND BREAST CANCER RISK

描述：(改编自《调查者摘要》) 假设宫内暴露于更高水平的 内源性妊娠雌激素可能在妊娠高血压疾病中发挥重要作用 乳腺癌的病因学。有几个可能的指标表明 孕期雌激素水平，但对其中两人来说，证据是 压倒性与各自强大的关系：妊娠毒血症 (先兆子痫/子痫)与低水平妊娠有关 雌激素；与怀孕之间存在正相关关系 雌激素和胎儿大小的测量。调查人员提议 检查这些指标与随后的乳房之间的关系 瑞典一项嵌套病例对照研究中的癌症发生。基地 人口由150,000多名妇女组成，她们在 乌普萨拉大学医院1874年至1954年在该县 从1920年到1857年，圣德斯瓦尔、法伦和爱斯基尔斯图罗的医院。 将确定这些妇女中发生乳腺癌的病例。 通过他们在瑞典癌症中唯一的国家注册号 1958-1990年期间的登记情况。对于每一种情况，第一个所生的雌性 案件发生后被录取的三位母亲将被选为 潜在的匹配控制。只有生活在瑞典和自由的控制者 从乳腺癌到被诊断为乳腺癌的时候 相应的案例将被纳入分析。追查合资格人士 控制是通过连续的教区数据进行的，瑞典人的死亡 注册中心和瑞典癌症注册中心。据估计， 大约1100例乳腺癌病例和3100个年龄和出生日期 配对的对照将包括在研究中。标准分析 条件Logistic回归方法用于配对病例对照研究 将进行研究。母亲的身长和胎盘重量将 被检查为风险决定因素。此外，母体 先兆子痫和有过妊娠史的子痫 分析以解决怀孕期间的特征或 母亲的体质特征更重要 决定因素。

DESCRIPTION: (Adapted from Investigator's Abstract) It has been hypothesized that intrauterine exposure to increased levels of endogenous pregnancy estrogens may play an important role in the etiology of breast cancer. There are several likely indicators of levels of pregnancy estrogens but for two of them the evidence is overwhelming and the respective relations strong: pregnancy toxemia (preeclampsia/eclampsia) is associated with low levels of pregnancy estrogens; and there is a positive correlation between pregnancy estrogens and measures of fetal size. The investigators propose to examine the relation between these indicators and subsequent breast cancer occurrence in a nested case-control study in Sweden. The base population consists of more than 150,000 women who were delivered at the Uppsala University Hospital from 1874 to 1954 and at the county hospitals of Sundsvall, Falun, and Eskilstuno from 1920 to 1857. Incident cases of breast cancer among these women will be identified through their unique national registration number in the Swedish cancer Registry during 1958-1990. For each case the females born to the first three mothers admitted after the case's mother will be selected as potential matching controls. Only controls living in Sweden and free from breast cancer until the time of diagnosis of breast cancer in the corresponding case will be included in the analysis. Tracing of eligible controls is done through successive parish data, the Swedish Death Registry, and the Swedish Cancer Registry. It is estimated that approximately 1,100 breast cancer cases and 3,100 age and birth-date matched controls will be included in the study. Standard analytic methods with conditional logistic regression for matched case-control studies will be carried out.Maternal length and placental weight will be examined as the risk determinants. In addition, maternal preeclampsia and eclampsia during the previous pregnancies will be analyzed to address whether features during the pregnancy or constitutional characteristics of the mother are the more important determinants.