DOPAMINE INVOLVEMENT IN OPIATE & STIMULANT DRUG REIN-

关于食物、水和大脑刺激奖励的研究 提供证据证明中枢多巴胺(DA)底物 代表着阳性神经生物学中的一个重要环节 增援。由于滥用药物被推定为通过 中枢激活大脑的自然奖励机制(S)吧 已经提出，这些DA通路也介导了 增强自我给药的特性。争议 然而，对于这样的DA系统是否构成基础，存在 所有积极的增强剂产生的奖励，或者是不同的 独立的系统在中枢神经系统内并行存在。这个 拟议中的研究旨在测试中枢 DA神经元介导两种主要神经递质的增强特性 滥用药物类别--精神运动兴奋剂 (苯丙胺、可卡因)和阿片类激动剂(吗啡和 海洛因)。外周和中枢多巴胺受体的作用 关于药物奖励的拮抗者将在两部小说中被考察 行为范式：部分强化灭绝检验 和激励性动机测试。这两种测试都有重要的 评估动物奖赏变化的优势 在测试时被下药的时间更长。拟议的研究 是否应提供与我们对以下内容的理解相关的信息 人类兴奋剂和鸦片类药物滥用；以及b)有助于阐明 中枢多巴胺神经元在药物奖赏神经基础中的作用。

Studies of food, water and brain-stimulation rewards have provided evidence that central dopaminergic (DA) substrates represent an important link in the neurobiology of positive reinforcement. Since abused drugs are presumed to act via a central activation of the brain's natural reward mechanism(s) it has been suggested that these DA pathways also mediate the reinforcing properties of self-administered drugs. Controversy exists, however, over whether or not such DA systems underlie the reward produced by all positive reinforcers or whether various independent systems exist in parallel within the CNS. The proposed research was devised to test the hypothesis that central DA neurons mediate the reinforcing properties of two major classes of abused drugs - the psychomotor stimulants (amphetamine, cocaine), and the opiate agonists (morphine and heroin). the effects of peripheral and central DA receptor antagonists on drug reward shall be examined in two novel behavioral paradigms: a Partial Reinforcement Extinction Test and an Incentive Motivation test. Both tests have the important advantage of assessing reward changes in animals that are no longer drugged at the time of testing. The proposed research should a) provide information relevant to our understanding of human stimulant and opiate drug abuse; and b) help elucidate the role of central DA neurons in the neural basis of drug reward.