A LONGITUDINAL NEUROPSYCHIATRIC COMPARISON OF TWO GROUPS

我们建议进行一项纵向观察研究， 男同性恋者HIV感染后神经精神后遗症 和异性恋的前静脉注射吸毒者。 利用 纵向重复测量设计，我们将评估60 曾接受美沙酮治疗的异性恋者 6个月时维持和60名血清阳性男性同性恋者 在三年的时间里。 我们也将遵循60 血清反应阴性的异性恋静脉注射毒品滥用者 维持组和60名血清阴性同性恋男性作为对照。 受试者将从San弗朗西斯科的两个现有队列中抽取 综合医院（SFGH）。 结果测量将强调精神病学， 医学和免疫功能分析以及神经心理学和 神经生理参数 将定期收集这些领域的数据 在三年的研究期间。 拟议研究的具体目标如下： 1. 估计以下疾病的发病率和患病率： HIV的神经心理和神经生理功能障碍 抗体呈阳性的男同性恋者及曾静脉注射海洛英者 用户，并确定是否存在组间差异。 2. 描述神经心理学的自然历史， 神经生理学功能障碍超过三年的随访期。 3. 为了检验神经心理学， 神经生理学、精神病学和免疫功能变量。 4. 以确定是否发生神经心理 和神经生理功能障碍可以被用作 特定疾病状态的后续发展 与艾滋病和/或ARC的诊断相关。 5. 为了促进有效筛选的发展， 人群神经精神功能障碍量表 研究了

We propose to conduct a longitudinal observational study of the neuropsychiatric sequelea of HIV infection in male homosexuals and heterosexual former intravenous drug abusers. Utilizing a longitudinal repeated measures design, we will evaluate 60 seropositive heterosexual intravenous drug abusers on methadone maintenance and 60 seropositive male homosexuals at six month intervals over a three year period. We will also follow 60 seronegative heterosexual intravenous drug abusers on methadone maintenance and 60 seronegative homosexual males as controls. Subjects will be drawn from two existing cohorts at San Francisco General Hospital (SFGH). Outcome measures will emphasize psychiatric symptomatology, medical and immune function analyses and neuropsychological and neurophysiological parameters. Data will be collected in each of these areas at regular intervals over the three year study period. Specific aims of the proposed study are as follows: 1. To estimate the incidence and prevalence of neuropsychological and neurophysiological dysfunction in HIV antibody positive homosexual males and former intravenous heroin users, and to determine whether intergroup differences exist. 2. To describe the natural history of neuropsychological and neurophysiological dysfunction over a three-year follow-up period. 3. To examine the interrelationships among neuropsychological, neurophysiological, psychiatric and immune function variables. 4. To determine whether the occurrence of neuropsychological and neurophysiological dysfunction may be used as a predictor of the subsequent development of particular disease states associated with diagnoses of AIDS and/or ARC. 5. To facilitate the development of an effective screening instrument for neuropsychiatric dysfunction in the populations studied.