BEHAVIORAL EFFECTS AND ABUSE OF DRUGS--ANTIHISTAMINES

组胺拮抗剂在治疗中通常具有麻烦的副作用。 应用，并可与其他药物联合使用 (e.g.,“T's and Blues”）。 初步 我们实验室的结果表明， 对猴子的行为有明显的影响， 药物滥用，可以保持持续的吸毒行为。 的 拟议研究的目的是确定药理学和 环境因素决定了这些药物如何影响行为。 的 组胺H-1和H-2拮抗剂对程序控制的 行为将通过确定其对抑制和 在不同环境条件下的非抑制反应， 将它们的效果与其他药物的效果进行比较， 药理学类别，并通过比较它们给药时的效果 通过中央和外围路线。 组胺的强化作用 拮抗剂将通过确定它们在引发和 保持自我管理行为，通过比较他们的效果， 其他药物的增强作用，通过确定功能 与其注射相关的环境刺激的特征， 并通过确定自我给药药物对其他正在进行的 行为 组胺拮抗剂和经常 将通过确定组胺如何 拮抗剂改变所选阿片剂如吗啡和吗啡的作用， 喷他佐辛和选择的苯二氮卓类，如地西泮。 总体看 拟议的研究将提供有关行动的基本信息， 组胺拮抗剂在改变和控制行为。

Histamine antagonists often have troublesome side effects in therapeutic application and may be used illicitly in combination with other drugs (e.g., "T's and Blues") by certain drug-dependent populations. Preliminary results from our laboratory indicate that selected histamine antagonists can have pronounced behavioral effects in monkeys and, like prototypical drugs of abuse, can maintain persistent drug-taking behavior. The objective of the proposed research is to identify pharmacological and environmental factors that determine how these drugs affect behavior. The actions of histamine H-1 and H-2 antagonists on scheduled-controlled behavior will be studied by determining their effects on suppressed and nonsuppressed responding under different environmental conditions, by comparing their effects with the effects of drugs from other pharmacological classes, and by comparing their effects when administered by central and peripheral routes. The reinforcing actions of histamine antagonists will be studied by determining their effects in initiating and maintaining self-administration behavior, by comparing their effects with the reinforcing effects of other drugs, by determining the functional characteristics of environmental stimuli associated with their injection, and by determining the effects of self-administered drugs on other ongoing behavior. Interactions between histamine antagonists and frequently co-administered drugs will be studied by determining how histamine antagonists modify the effects of selected opiates, such as morphine and pentazocine, and selected benzodiazepines, such as diazepam. Overall, the proposed research will provide fundamental information about the actions of histamine antagonists in altering and controlling behavior.