LONGITUDINAL STUDY OF THE IV-AIDS EPIDEMIC

讨论了许多关于艾滋病毒/艾滋病的最关键问题， 流行病需要长期数据。 因此，本提案寻求 基金进行艾滋病毒感染的非临床纵向研究， 614个静脉输液器样本。他们是被街头招募的 在以前的研究中，三个小城市的角落。 三次 在一年的时间里，上一项研究详细采访了静脉吸毒者， 关于性别和针头使用，受试者每次都接受测试， 艾滋病。 一半的受试者都接触到了社区范围的外展活动， 预防艾滋病的传播。 利用这个机会- 年数据库和持续访问样本，该提案旨在 每年进行四次纵向研究， 后续面谈和艾滋病毒检测。 目前的工作人员已经取得了 在最后一波访谈中对这些受试者的随访率很高， 项目文件中有大量关于 科目 因此，该研究预计将完成随访， 90%的受试者，并将使用新的分析技术， 调整损耗。 由此产生的数据将用于评估 艾滋病预防的长效性、稳定性决定 危险行为的变化，描述血清转换率随时间的变化， 并前瞻性地研究感染率趋于平稳的趋势。 该项目还将使用计算机化地图来分析 居住地和艾滋病毒状况，以便在地理上追踪疫情 随着时间的推移，并将审查艾滋病对无家可归者和非 无家可归的静脉注射吸毒者

Answering many of the most critical questions concerning the IV-AIDS epidemic requires long-term data. Accordingly, this proposal seeks funds to conduct a longitudinal study of HIV infection in a non-clinical sample of 614 IVDUs. They were recruited by outreach from the street corners of three small cities during a previous study. Three times during a year, the previous study interviewed the IVDUs in detail regarding sex and needle use, and the subjects were tested each time for HIV. Half the subjects were exposed to a community-wide outreach intervention to prevent the spread of AIDS. Capitalizing on this one- year database and continuing access to the sample, the proposal aims to produce a five-year longitudinal study by conducting four more yearly follow-up interviews and HIV tests. The current staff has achieved a high follow-up rate with these subjects in the last wave of interviews, and the project files have extensive location information on the subjects. The study therefore anticipates completing follow-ups with 90% of the subjects each-year, and will use new analysis techniques to adjust for attrition. The resulting data will be used to assess the long-term effectiveness of AIDS prevention, determine the stability of changes in risk behaviors, describe the sero-conversion rate over time, and prospectively study the tendency of the infection rate to level off. The project will also use a computerized map to analyze the data on residence and HIV status in order to track the epidemic geographically over time, and will examine the impact of AIDS on homeless and non- homeless IVDUs over time.