Development and Commercialisation of a Second Generation Rapid Diagnostic Test (RDT) for Human African Trypanosomiasis (HAT) and other Kinetoplastida

这项研究的总体目标是完成进一步开发和商业化的新的测试，用于检测和诊断寄生虫人类非洲锥虫（HAT或昏睡病），建立和完成以前资助的BBSRC应用程序。HAT威胁着非洲撒哈拉以南地区的4340万人，是采采蝇传播的寄生虫感染的结果，开发新的、更可靠和更经济的诊断生物标志物和检测方法至关重要，特别是对于监测和遏制剩余中高风险疫源地的传播。我们的方法也适用于开发新的诊断测试，用于诊断、监测和监视寄生虫病引起的其他疾病。因此，我们还将利用我们的技术开发新的诊断测试，用于商业和社会重要性的锥虫和动质体疾病引起的其他疾病。

The overall aim of this research is to complete the further development and commercialisation of new tests for the detection and diagnosis of the parasite Human African Trypanosomiasis (HAT or sleeping sickness), building upon and completing previously funded BBSRC applications. HAT threatens 43.4 million people in the sub-Saharan area of Africa, is the result of infection by parasites transmitted by the tsetse fly, and the development of new, more reliable and economic diagnostic biomarkers and assays is essential, particularly for surveillance and to curb transmission in the remaining moderate to high risk foci. Our approach is also amenable to the development of new diagnostic tests for the diagnosis, monitoring and surveillance of other diseases caused by parasite diseases. We will therefore also apply our technology to the development of new diagnostic tests for other diseases caused by Trypanosomes and Kinetoplastid diseases of commercial and social importance.