WATER-BORNE FLUORIDE AND BONE MINERAL DENSITY

描述（改编自研究者摘要）：已 假设社区水氟化可以防止骨骼 减少骨折的风险。 然而，数据 支持这一假设证据尚不存在。 最近的三项研究表明 生活在水中氟化物含量为4.0 ppm的社区的妇女 系统具有较低水平皮质骨， 与生活在百万分之1.0社区的妇女相比， 氟化 另一项研究表明，生活在 有氟化水系统的地区髋部骨折的风险更高 比那些生活在氟化物含量可以忽略不计的地区的人更容易受到影响。 饮用水 拟议研究的目的是澄清 不同水平的水载氟化物与 骨质减少，通过老年人骨矿物质密度降低来测量 60岁以上 将收集三个长期居民的数据 在俄勒冈州东部和华盛顿也有类似的社区。 社区 水的氟化物含量为0.06、1.0和2.5 ppm。 大约105 三个社区各有105名妇女和男子将接受采访， 关于已知的混杂变量， 通过双能X线吸收测定法进行评价。将对数据进行分析 为了研究这三种人的骨密度是否不同， 氟化物水平，当密度在统计学上调整值时 的混淆变量。将提供关于是否 饮用氟化水的人的骨矿物质水平不同， 密度，这对现有的 社区水氟化的公共政策。

DESCRIPTION (adapted from the Investigator's abstract):It has been postulated that community water fluoridation may prevent skeletal bone loss and reduce the risk of osteoporotic fractures. However, data to support this hypothesis are not available. Three recent studies indicate that women living in communities with 4.0 ppm fluoride in the water system have lower levels of cortical bone and an increased risk of fracture when compared to women living in communities with 1.0 ppm fluoride. Another study indicates that both women and men living in areas with fluoridated water systems are at higher risk of hip fractures than those living in areas with negligible levels of fluoride in the drinking water. The purpose of the proposed study is to clarify the relationship between varying levels of water-borne fluoride and osteopenia as measured by decreased bone mineral density in adults aged 60 or older. Data will be collected on long-term residents of three similar communities in eastern Oregon and Washington. The communities have water fluoride levels of 0.06, 1.0, and 2.5 ppm. Approximately 105 women and 105 men in each of the three communities will be interviewed regarding known confounding variables and have their bone density evaluated via dual energy x-ray absorptiometry. The data will be analyzed to investigate whether bone mineral density differs between the three fluoride levels, when the density is adjusted statistically for values of the confounding variables. Evidence would be provided about whether people consuming fluoridated water have a different level of bone mineral density, which has important implications in regard to the existing public policy of community water fluoridation.