VITAMIN SUPPLEMENTATION IN THE TREATMENT OF ORAL LESIONS

这项建议的主要目标是评估 补充维生素(β-胡萝卜素、维生素C和维生素E) 口腔粘膜病变的治疗。具体来说，我们计划招聘200名 有口腔粘膜损害的患者超过三年。这个 将获得以下数据：诊断性活检、测量 病变大小、临床照片、血清和组织样本以确定 维生素水平、暴露于危险因素和节食史。 临床和生化评估将分别进行1、3、6和9个月 在开始补充之后。这将允许统计 口腔病变变化与血液中维生素水平的比较 和组织，暴露于危险因素，以及饮食。根据样本 大小，重复测量ANOVA检测 四组之间的差异为81%，多项式的差异为86% 逻辑分析。 本次双盲随机临床试验的意义在于 它将确定补充这个剂量的维生素是否可以减少 口腔黏膜病变的大小或。

The primary objective of this proposal is to evaluate the efficacy of vitamin supplementation (beta-carotene, vitamin C, and vitamin E) in the treatment of oral mucosal lesions. Specifically, we plan to recruit 200 patients with oral mucosal lesions over a three year period. The following data will be obtained: diagnostic biopsy, measurement of the lesion size, clinical photographs, serum and tissue samples to determine vitamin levels, exposure to risk factors, and diet history. Clinical and biochemical evaluations will occur 1, 3, 6, and 9 months after initiation of supplementation. This will permit a statistical comparison of changes in the oral lesions to vitamin levels in the blood and tissue, exposure to risk factors, and diet. Based on the sample size, the estimated power of the repeated measures ANOVA to detect a difference among the four groups is 81% and is 86% for multinomial logistic analysis. The significance of this double-blind randomized clinical trial is that it will determine if vitamin supplementation at this dosage can reduce the size or oral mucosal lesions.