H-2-LINKED CONTROL OF STEROID SUSCEPTIBILITIES

该项目旨在获得有关H-2连锁基因的新信息 这会影响小鼠对可的松诱导的裂隙的易感性 味觉。我们建议通过测试一些基因来更精确地定位这个基因 具有重组体H-2染色体的同源小鼠品系 高易感单倍型和低易感单倍型之间的差异。初步证据 表明H-2K和T基因座之间的基因图谱，所以实验 已经被设计用来仔细分析这个基因区域。脱氧核糖核酸 已被映射到H-2K和T之间区域的多态将 在与唇裂有关的同源基因系中进行研究 味觉敏感度。 也有证据表明H-2连锁基因影响易感性。 性类固醇对胎鼠男性化和女性化的影响。 我们建议更精确地定位这一基因，并确定它是否 与控制腭裂易感性的基因不同。最后， 我们建议确定小鼠对性类固醇的敏感性- 诱导淋巴细胞耗竭受H-2连锁基因的影响。

This project is designed to yield new information about an H-2-linked gene which affects the susceptibility of mice to cortisone-induced cleft palate. We propose to map this gene more precisely by testing a number of congenic strains of mice which have H-2 chromosomes that are recombinants between high and low susceptibility haplotypes. Preliminary evidence suggests that the gene maps between H-2K and the T locus, so experiments have been designed to analyze this genetic region closely. DNA polymorphisms that have been mapped to the region between H-2K and T will be studied in congenic lines that are informative with respect to cleft palate susceptibility. There is also evidence that an H-2-linked gene affects the susceptibility of fetal mice to the masculinizing and feminizing effects of sex steroids. We propose to map this gene more precisely, and to determine whether it differs from the gene which controls cleft palate susceptibility. Finally, we propose to determine whether the susceptibility of mice to sex steroid - induced lymphocyte depletion is affected by H-2-linked genes.