CARBOHYDRATE METABOLISM AND CATECHOLAMINES

本提案的长期目标是说明以下一些特点 调节交感神经系统活动的因素 和肾上腺髓质，从而帮助定义 儿茶酚胺在新陈代谢调节和维持中的作用 内部环境。利用动力学技术评估 用去甲肾上腺素比率测定交感神经系统活动 实验动物肾上腺神经支配组织的周转 本计划中计划的研究将调查以下领域： 1)不同营养素对交感神经活动的影响 神经系统、肾上腺髓质和外周多巴胺能 系统；2)协调饮食摄入的代谢信号 交感肾上腺和多巴胺能活动；3)交感肾上腺和 多巴胺能反应在多种生理和病理生理学中的作用 包括实验性糖尿病，肾功能不全，怀孕， 缺氧和发烧。 由于交感神经系统在 生热和血压的调节，这些研究检查了 饮食摄入量对这一系统的活动可能有影响 肥胖症的发病机制和治疗意义 高血压。交感神经肾上腺和多巴胺能改变的鉴别 其他生理和病理生理状态的反应可能有 由于刺激或阻断的有效手段而产生的治疗意义 儿茶酚胺的作用很容易获得。

The long term objective of the present proposal is to characterize some of the factors that regulate the activity of the sympathetic nervous system and the adrenal medulla and thereby help define the role played by catecholamines in the regulation of metabolism and in the maintenance of the internal environment. Utilizing kinetic techniques to asses sympathetic nervous system activity by measuring the rate of norepinephrine turnover in adrenergically innervated tissues of experimental animals, the studies planned in this program will investigate the following areas: 1) The effect of different nutrients on the activity of the sympathetic nervous system, the adrenal medulla, and the peripheral dopaminergic system; 2) The metabolic signals that coordinate dietary intake with sympathoadrenal and dopaminergic activity; and 3) The sympathoadrenal and dopaminergic responses in a variety of physiological and pathophysiological states including experimental diabetes, renal insufficiency, pregnanay, hypoxia, and fever. Since the sympathetic nervous system plays a critical role in the regulation of thermogenesis and blood pressure, the studies examining the effect of dietary intake on the activity of this system may have implications for the pathogenesis and treatment of obesity and hypertension. Identification of altered sympathoadrenal and dopaminergic responses in other physiological and pathophysiological states may have therapeutic implications since effective means of stimulating or blocking the actions of catecholamines are readily available.