CARBOHYDRATE METABOLISM AND CATECHOLAMINES

本提案的长期目标是描述一些 调节交感神经系统活动的因素 和肾上腺髓质，从而帮助确定 在调节代谢和维持 内部环境。 利用动力学技术评估 交感神经系统活动通过测量去甲肾上腺素的速率 在实验动物的肾上腺素能神经支配的组织中， 该方案计划进行的研究将调查以下领域： 1)不同营养素对交感神经活性的影响 神经系统、肾上腺髓质和外周多巴胺能 2）协调饮食摄入的代谢信号， 交感肾上腺和多巴胺能活性;和3）交感肾上腺和 多巴胺能反应在各种生理和病理生理 包括实验性糖尿病、肾功能不全、妊娠、 缺氧和发烧 由于交感神经系统在神经系统中起着关键作用， 调节产热和血压，研究检查 饮食摄入对该系统活性的影响可能具有 肥胖症的发病机制和治疗的意义， 高血压 交感肾上腺和多巴胺能改变的鉴定 在其他生理和病理生理状态下的反应可能 治疗意义，因为有效的刺激或阻断手段 儿茶酚胺的作用是容易获得的。

The long term objective of the present proposal is to characterize some of the factors that regulate the activity of the sympathetic nervous system and the adrenal medulla and thereby help define the role played by catecholamines in the regulation of metabolism and in the maintenance of the internal environment. Utilizing kinetic techniques to asses sympathetic nervous system activity by measuring the rate of norepinephrine turnover in adrenergically innervated tissues of experimental animals, the studies planned in this program will investigate the following areas: 1) The effect of different nutrients on the activity of the sympathetic nervous system, the adrenal medulla, and the peripheral dopaminergic system; 2) The metabolic signals that coordinate dietary intake with sympathoadrenal and dopaminergic activity; and 3) The sympathoadrenal and dopaminergic responses in a variety of physiological and pathophysiological states including experimental diabetes, renal insufficiency, pregnanay, hypoxia, and fever. Since the sympathetic nervous system plays a critical role in the regulation of thermogenesis and blood pressure, the studies examining the effect of dietary intake on the activity of this system may have implications for the pathogenesis and treatment of obesity and hypertension. Identification of altered sympathoadrenal and dopaminergic responses in other physiological and pathophysiological states may have therapeutic implications since effective means of stimulating or blocking the actions of catecholamines are readily available.