EFFECTS OF ORTHOTOPIC LIVER TRANSPLANTATION

计划在人类身上进行60到80例原位肝移植 从1982年开始的一年，略多于一半的案件发生在 成年人。对于这些患者来说，比起 过去的计划包括更好的免疫抑制，完善 移植技术程序，代谢事件研究 肝脏置换术后，对小鼠的生长发育进行评估 儿童，描述以下神经精神变化 移植，评估新的传染病模式， 在环孢素A和类固醇治疗下出现，准确 同种异体肝移植的功能评价及进一步研究 先天的新陈代谢错误。计划进行动物工作，以改善 同种异体肝移植保存技术评价新方案 免疫抑制的潜在临床应用，并大量检测 放弃辅助性肝移植的潜在用途 急性肝衰竭患者或门静脉高压症患者 血栓形成，不能接受肝脏置换治疗。

Sixty to 80 orthotopic liver transplantations in humans are planned for the year beginning with 1982, slightly more than half of the cases being in adults. For these patients a variety of improvements from that offered in the past are planned including better immunosuppression, refinements of the technical procedure of transplantation, study of the metabolic events following liver replacement, assessment of the growth and development of children, delineation of the neuropsychiatric changes following transplantation, assessment of the new pattern of infectious disease which is emerging under therapy with cyclosporin A and steroids, accurate assessment of the function of the homografted livers and further studies of inborn errors of metabolism. Animal work is planned to improve the preservation techniques of liver homografts, to evaluate new programs of immunosuppression for potential clinical use, and to examine the largely abandoned procedure of auxiliary liver transplantation for potential use in patients with acute liver failure or in patients whose portal vein has thrombosed and who cannot be treated with liver replacement.