EFFECTS OF ORTHOTOPIC LIVER TRANSPLANTATION

60至80例人类原位肝移植计划用于 从1982年开始的一年中， 成年人了 对于这些患者， 过去的计划包括更好的免疫抑制， 移植技术程序、代谢事件的研究 肝脏替代后，评估生长和发育， 儿童，描述神经精神变化， 移植，评估新的传染病模式， 在环孢菌素A和类固醇治疗下出现，准确 同种移植肝的功能评价及移植肝的进一步研究 先天性代谢缺陷 动物工作计划，以改善 肝移植物保存技术，以评估新的方案， 潜在的临床应用的免疫抑制，并检查在很大程度上 放弃辅助性肝移植手术，以用于 急性肝衰竭患者或门静脉有 血栓形成，不能用肝脏替代治疗。

Sixty to 80 orthotopic liver transplantations in humans are planned for the year beginning with 1982, slightly more than half of the cases being in adults. For these patients a variety of improvements from that offered in the past are planned including better immunosuppression, refinements of the technical procedure of transplantation, study of the metabolic events following liver replacement, assessment of the growth and development of children, delineation of the neuropsychiatric changes following transplantation, assessment of the new pattern of infectious disease which is emerging under therapy with cyclosporin A and steroids, accurate assessment of the function of the homografted livers and further studies of inborn errors of metabolism. Animal work is planned to improve the preservation techniques of liver homografts, to evaluate new programs of immunosuppression for potential clinical use, and to examine the largely abandoned procedure of auxiliary liver transplantation for potential use in patients with acute liver failure or in patients whose portal vein has thrombosed and who cannot be treated with liver replacement.