NEURAL EFFECTS OF LOW-LEVEL MICROWAVES

在初步的实验中，我们发现老鼠会产生一种短暂的 低强度脉冲微波急性暴露后即刻体温升高 辐照（2450 MHz，2 Mus脉冲，500 pps，1 mW/cm 2，SAR 0.6 W/kg）。 在相同平均入射功率下的连续波微波照射 密度未能引起类似的效果。 因此，脉冲微波诱导 可以通过用以下药物治疗动物来减弱实验后的体温过高 麻醉剂拮抗剂、血清素拮抗剂和前列腺素合成 阻滞剂。 我们建议使用这种可靠且易于测量的效果， 微波作为比较不同的效果的终点 微波辐射参数，包括功率密度和持续时间， 辐照 圆偏振和线偏振微波的效应 也将进行比较。 实验还旨在进一步探讨神经机制， 实验后体温过高 可能与脉搏有关 微波诱导的听觉效应在高温将研究 耳蜗病变 中枢和垂体β-内啡肽的参与将 通过弓状核毁损、垂体切除和地塞米松进行研究 治疗 微波暴露对大鼠脑内β-内啡肽水平的影响 还将研究血浆、脑下垂体和大脑。 在另一个初步实验中，我们发现， 微波衰减安非他明诱导的大鼠体温过高。 这 作用可被纳洛酮阻断，并且是经典可调节的。 的 条件作用也是纳洛酮可阻断的。 实验被提议为 研究微波对阿朴吗啡低温的影响 和刻板症，酒精低温，和吗啡诱导的僵住症， 致命性也可被麻醉剂拮抗剂阻断 有条件的 预计拟议研究的结果将进一步 了解神经机制介导的影响，急性 反复暴露在低强度微波中

In preliminary experiments, we found that rats developed a transient hyperthermia immediately after acute exposure to low-level pulsed microwave irradiation (2450 MHz, 2 Mus pulse, 500 pps, 1 mW/cm2, SAR 0.6 W/kg). Continuous-wave microwave exposure at the same average incident power density failed to cause a similar effect. Thus, pulsed microwave-induced postexposure hyperthermia can be attenuated by treating the animals with narcotic antagonists, serotonin antagonists, and prostaglandin synthesis blockers. We propose to use this reliable and easily measurable effect of microwaves as an end point for comparison of the effects of the different parameters of microwave irradiation including power density and duration of irradiation. Effects of circularly versus linearly polarized microwaves will also be compared. Experiments are also designed to further explore the neural mechanisms of the postexposure hyperthermia. Possible involvement of the pulsed microwave-induced auditory effect in the hyperthermia will be studied by cochlear lesion. Involvements of central and pituitary Beta-endorphin will be studied by arcuate nucleus lesion, hypophysectomy, and dexamethasone treatment. Effects of microwave exposure on levels of Beta-endorphin in plasma, the pituitary gland and the brain will also be studied. In another preliminary experiment, we found that acute exposure to pulsed microwaves attenuated amphetamine-induced hyperthermia in the rat. This effect can be blocked by naloxone and is classically conditionable. The conditioned effect is also naloxone-blockable. Experiments are proposed to investigate whether the effects of microwaves on apomorphine-hypothermia and stereotypy, ethanol-hypothermia, and morphine-induced catalepsy and lethality are also blockable by narcotic antagonists and classically conditionable. It is expected that the results from the proposed research will further understanding of the neurological mechanisms mediating the effects of acute and repeated exposure to low-level microwaves.