REFRACTIVE KERATOPLASTY: A LABORATORY INVESTIGATION

屈光性角膜移植是一种改变角膜的外科手术 用于矫正眼睛屈光不正的曲率。 手术的范围可以从制作精确的手术切口到 角膜到车削异体或人基质的植入 皮孔菌。此应用程序针对使用中的调查 同种异体，特别是水凝胶，角膜内晶状体(ICL) 屈光性角膜移植。水凝胶材料目前正被用于 长时间佩戴含水率高(50%-80%)的隐形眼镜 对溶质具有很强的渗透性。由于这些特点，沿着 具有精确车削给定功率和基准曲线的能力， 水凝胶的非反应性组织反应、稳定性和可用性 材料，这是一个绝佳的选择作为ICL。然而，它是一种异国情调 物质进入身体，永远不会像人类那样融入组织 捐献的角膜可能是。人体供体角膜是生物学上的完美选择 作为一种植入材料，但更难精确地车削， 提供不太可靠的材料供应，可能在维度上也不太可靠 稳定的豆状突起。Long将评估水凝胶ICLS的疗效 术语非人灵长类临床和形态研究，以定义 程序的可预测性和稳定性。一种光学分析的方法 数据将被用来帮助预测手术结果。这个 ICL对角膜瘢痕形成、肿胀、 将评估压力、基质弹性、耗氧量等。 水凝胶材料的物理特性，即渗透性， 将定义药物的摄取和释放、弹性性质等。这个 研究工作将在人类临床之前确定水凝胶ICL的有效性 审判。

Refractive keratoplasty is a surgical procedure to alter the cornea's curvature for the purpose of correcting the refractive error of the eye. The procedure can range from producing precise surgical incisions in the cornea to implantation of either a lathe cut alloplastic or human stroma lenticule. This application is directed toward an investigation in the use of alloplastic, specifically hydrogel, intracorneal lenses (ICLs) for refractive keratoplasty. Hydrogel materials are presently being used for extended wear contact lenses that are high (50-80%) in water content and are very permeable to solutes. Because of these characteristics, along with the ability to precisely lathe cut a given power and base curve, the non-reactive tissue response to hydrogels, stability and availability of material, it is an excellent choice as an ICL. Yet, it is a foreign substance to the body and will never be integrated into the tissue as human donor cornea may be. Human donor cornea is biologically the perfect choice as an implant material, but is more difficult to precisely lathe cut, offers a less reliable supply of material and possibly a less dimensionally stable lenticule. The efficacy of hydrogel ICLS will be evaluated by long term non-human primate clinical and morphological studies to define the predictibility and stability of the procedure. An optical analysis of the data will be performed to aid in predicting the surgical outcome. The effect of the ICL on corneal physiology such as scarring, swelling, pressure, stromal elasticity, oxygen consumption, etc., will be assessed. The physical characteristics of the hydrogel material, i.e., permeability, drug uptake and release, elastic properties, etc., will be defined. The work will establish the efficacy of hydrogel ICLs prior to human clinical trials.