SCLERAL IMPLANTS FOR MYOPIA

人的眼睛在生命的前3年迅速生长， 从出生时的平均17.3 mm轴向长度约为5 mm。 在正常情况下，轴向长度仅增加1 到14岁时完全生长。 更大的伸长导致近视， 缺乏常见的一大部分人口，这通常是 可以用眼镜或隐形眼镜矫正。 然而，在某些人身上， 地球仪继续变长， 通过屈光矫正恢复功能性视力。 因为， 视网膜不能跟上巩膜的扩张， 眼睛有很大的风险视网膜破裂，脱落和失明。 病理性近视与巩膜结构性变弱有关。 这项生物材料研究提案的目标是确定是否 手术植入的加固带安全地支撑巩膜， 防止眼睛的延长，并开发一个最佳巩膜 加强带 初步工作将致力于确定 候选巩膜加固材料（供体）的生物学效应 巩膜、合成聚合物）。 那么， 选择巩膜植入物对猫眼睛生长的影响 快速发展将得到评估。 轴向长度的变化将 通过超声波A扫描监测。 黄斑的情况，视网膜 血流和视神经乳头将通过检眼镜检查进行评估 并通过眼底照相术记录， 通过检眼镜检查进行评价并通过眼底照相进行记录。 解剖学检查将验证带的位置及其 对眼外结构的严重影响。 植入物的相容性 材料与眼组织在细胞水平和性质的 将检查植入物和眼睛之间的界面 组织学上。 成功的猫科动物研究之后， 小猴子 在适当的时候，在取得有希望的成果之后， 建议在晚期患者中进行临床试验 病理性近视，然后在近视患者谁是最大的风险， 发展到严重的轴向伸长。 建议的结果 研究还将适用于合成聚合物在 眼睛，如巩膜，肌肉补丁，以防止疤痕，和 组织增强。

The human eye grows rapidly over the first 3 years of life; the increase from an average 17.3 mm axial length at birth is approximately 5 mm. Under normal conditions, the axial length increases only an additional 1 mm to full growth by age 14. Greater elongation causes myopia, a visual deficiency common to a large segment of the population, which is usually correctable with spectacles or contact lenses. In some people, however, the globe continues to lengthen to such an extent that it is difficult to restore functional vision by refractive correction. Because the growth of the retinal does not keep pace with the expansion of the sclera, these eyes are at great risk of retinal breaks, detachment, and blindness. Pathologic myopia is associated with structural weakening of the slcera. The goals of this biomaterials research proposal are to determine whether surgically implanted reinforcement bands safely support the sclera to prevent the lengthening of the eye and to develop an optimal sclera reinforcement band. Initial efforts will be directed toward determining the biological effects of candidate scleral reinforcement materials (donor sclera, synthetic polymers) on the rabbit eye. Then, the effects of selected scleral implants on the growth of the feline eye during a period of rapid development will be evaluated. Changes in axial length will be monitored by ultrasonic A-scan. The condition of the macula, the retinal blood flow, and the optic nerve head will be evaluated by ophthalmoscopy and documented by fundus photography and the optic nerve head will be evaluated by ophthalmoscopy and documented by fundus photography. Anatomic examinations will verify the placement of the bands and their gross effects on extraocular structures. The compatibility of the implant materials with ocular tissues at the cellular level and the nature of the interface between the implants and the eye will be examined histologically. Successful feline studies will be followed by trials in infant monkeys. When appropriate, promising results will be followed by a proposal to conduct clinical trials in patients who have advanced pathologic myopia, and then in myopia patients who are at greatest risk of progressing to severe axial elongation. The results of the proposed studies will also be applicable to other uses of synthetic polymers in the eye such as for scleral buckles, muscle patches to prevent scarring, and tissue augmentation.