The molecular mechanism of bacterial ABC toxins

该项目旨在建立ABC家族的细菌蛋白毒素，这是许多自然发生的害虫细菌病原体的主要毒力因子，代表了细胞和其他生物体可能用来将生物活性蛋白传递给特定细胞的蛋白质机制。ABC毒素是多种自然发生的害虫病原菌的主要毒力因子。该项目旨在确定ABC毒素代表了一种新的蛋白质机制，可以更广泛地用于整个细胞和其他生物体，以高度细胞特异性的方式指导生物活性蛋白的细胞间传递。该项目希望这些发现能够开发基于ABC毒素的生物农药，以及用于生物技术的通用细胞间蛋白质递送装置。

This project aims to establish that the ABC family of bacterial protein toxins, the main virulence factors in many species of naturally-occurring bacterial pathogens of insect pests, represent a protein machinery that cells and other organisms may use to deliver bioactive proteins to specific cells. ABC toxins are the main virulence factors in many species of naturally-occurring bacterial pathogens of insect pests. This project aims to establish that ABC toxins represent a new protein machinery that may be used more widely throughout cells and other organisms to direct the intercellular delivery of bioactive proteins in a highly cell-specific manner. The project expects these findings to enable the development of biopesticides based on ABC toxins, and generic intercellular protein delivery devices for biotechnological use.