麻痹——手术和麻醉期间的拮抗作用-猫眼课题宝

麻痹——手术和麻醉期间的拮抗作用

批准号：

3273882

负责人：

RONALD D MILLER

金额：

$15.67万

依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

依托单位国家：

美国

项目类别：

财政年份：

1979

资助国家：

美国

项目状态：

已结题

起止时间：

1979-04-01 至 1985-11-30

来源：

https://reporter.nih.gov/project-details/3273882

关键词：

anesthesia drug adverse effect drug metabolism human old age (65+) human subject liver disorder mathematical model neostigmine neuromuscular blocking agents paralysis pharmacokinetics pyridostigmine renal failure surgery tubocurarine

中文摘要

翻译

初步建立了药代动力学和药效学数学模型。可在临床手术室环境中不受干扰地使用以及常规的临床护理。我们测定了药物动力学和常用神经肌肉阻滞剂(D-管胡萝卜碱)的药效学和Pancruonium)和非去极化神经肌肉的常见拮抗剂封锁(新斯的明和吡斯的明)。为了完成这些研究，必须开发合适的方法来测量体液中的药物浓度。我们实施了一种免疫分析技术来测定d-管库拉林；高建立了高效液相色谱法测定新斯的明的方法。体液中含有吡啶斯的明。最近，一种质谱学方法是为测量体液中的潘库溴铵浓度而开发的。然后我们测定肾功能衰竭、肝病及体温过低对上述药物的药代动力学和药效学。

英文摘要

A mathematical pharmacokinetic and pharmacodynamic model was initially developed which can be used in the clinical operating room setting without interfering with routine clinical care. We determined the pharmacokinetics and pharmacodynamics of commonly used neuromuscular blocking drugs (d-tubocurarine and pancruonium) and common antagonists of a non-depolarizing neuromuscular blockade (neostigmine and pyridostigmine). In order to complete these studies a suitable assay to measure drug concentration in body fluids had to be developed. We implemented an immunoassay technique for measuring d-tubocurarine; a high performance liquid chromatography method was developed for measuring neostigmine and pyridostigmine in body fluids. Most recently, a mass spectrometry method was developed for measuring pancuronium concentrations in body fluids. We then determined the influence of renal failure, hepatic disease and hypothermia on the pharmacokinetics and pharmacodynamics of the drugs listed above.

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