ASYMMETRIC SYNTHESIS OF POLYETHER ANTIBIOTICS

该项目的主要目标是设计和执行 离子载体抗生素溶细胞素的对映选择性合成， ferensimycin、alborixin和X-206。 在这个项目的过程中， 两类离子载体的绝对构型将是明确的， 用化学方法测定。 上述综合研究将 在很大程度上依赖于这个实验室正在开发的不断发展的概念， 非对称感应区。 相关的新化学概念 对非环状体系中立体化学控制的一般问题， 处理。 这项研究的长期目标属于理性 设计可用作聚合物的有机分子， 选择性膜离子载体和手性催化剂。

The principal objectives of this project are to design and execute enantioselective syntheses of the ionophore antibiotics lysocellin, ferensimycin, alborixin and X-206. During the course of this project the absolute configuration of both classes of ionophores will be unequivocally determined by chemical methods. The synthesis studies described above will rely heavily upon evoling concepts being developed in this laboratory in the area of asymmetric induction. Related new chemical concepts relevant to the general issue of stereochemical control in acyclic systems will be addressed. The long range goals of this research pertain to the rational design of poly-ligating organic molecules which can be employed as selective membrane ion carriers and chiral catalysts.