STRUCTURAL INVESTIGATIONS OF MODEL ACTION OF DRUGS

研究计划的目标是（i）阐明 理化性质与化学结构的关系 药物，以及（ii）也要了解确切的分子机制， 这些药物抑制核酸和蛋白质的合成。 毒品 选择用于研究的是利福霉素SV、利福霉素S、全霉素、诺加霉素， 阿霉素，阿克拉霉素，斯替菲霉素，安曲霉素，西比罗霉素， tomaymycin，新丝霉素，短杆菌肽，维吉尼亚霉素，astreogrycin， 色霉素、橄榄霉素、棘霉素、博来霉素、bouvardins、edeines和 丝裂霉素 这些药物与核酸片段的复合物 蛋白质将被研究。 调查使用的方法 将主要是X射线晶体学，核磁共振和计算机图形学。 的 这些研究的结果将有助于揭示相互作用的网站， 这些药物的目标分子，从而模型的药物受体 相互作用是可以假设的。 此外，还可以对 可以假定药物增强其治疗选择性。

The objectives of the research program are (i) to elucidate the relationship between physiochemical properties and chemical structures of the drugs, and (ii) also to understand the exact molecular mechanism by which these drugs inhibit nucleic acid and protein synthesis. The drugs chosen for studies are rifamycin SV, rifamycin S, holomycins, nogalamycins, adriamycins, aclacinomycin, steffimycin, anthramycin, sibiromycin, tomaymycin, neothramycin, gramicidins, virginiamycin, astreogrycin, chromomycin, olivomycin, echinomycin, bleomycin, bouvardins, edeines, and mitomycins. Also complexes of these drugs with fragments of mucleic acids and proteins will be investigated. The methods used for investigations will be mainly X-ray crystallography, NMR and computer graphics. The results of these investigation will help reveal the sites of interaction of these drugs to the target molecules and thus models for drug-receptor interaction can be postulated. Also modifications to the structures of the drugs can be postulated to enhance their therapeutic selectivity.