INVESTIGATIONS OF THE CHORISMATE PATHWAY

该计划的目标包括合成的类似物 分支酸盐和预苯酸盐及其作为底物活性的研究 分支酸盐或预苯酸盐的抑制剂或自杀底物 脱氢酶。 这些靶酶催化酪氨酸的生物合成 以及细菌、真菌和高等植物中的苯丙氨酸。 远程 目标是发现类似物，将是有用的抗菌剂 和抗真菌剂。 其他 目标包括生物合成中间体的全合成， 分支酸途径和物质的合成，将用于 用分支酸盐和预苯酸盐进行机理研究 脱氢酶。

The objectives of the program include the synthesis of analogs of chorismate and prephenate and investigations of their activity as substrate inhibitors or suicide substrates for chorismate mutase or prephenate dehydrogenase. These target enzymes catalyze the biosynthesis of tyrosine and phenylalanine in bacteria, fungi, and higher plants. The long-range goal is the discovery of analogs that will be useful antibacterial agents and antifungal agents by selective blocking of target enzymes. Other objectives include the total synthesis of biosynthetic intermediates in chorismate pathway and the synthesis of substances that will be used for mechanistic investigations with chorismate mutase and prephenate dehydrogenase.