SYNTHESIS AND CHEMISTRY OF NEW POLYCYCLIC SYSTEMS

高对称性和高应变的刚性、多环笼系统具有特殊的 对它们的化学和AS的基本方面感兴趣 自然界中找不到的新的和不寻常的材料的来源。立方烷， 一个非帕雷尔的例子，现在可以非常容易地在 足够的数量将该系统用作实际的起始材料 其他特殊环系的合成，如氮杂高立方香酮， 脱氢立方烷、氮杂立方烷、1，1‘：3，3’-双环丁烷等。 重要的是对明确但不寻常的分子的影响进行了探索 结构对键合、反应性和其他性能的影响 在这项工作的过程中进行了评估。作为此类化合物及其 衍生物是一种全新的环系，它们呈现出非常新颖的类型 发现新的药用价值的机会 材料。此外，由于碳骨架的几何要求 这些系统远远不是普通的，战术综合是一种 不同寻常的挑战。因此，这项工作还将导致 开发建造和操纵骨骼的新方法 复杂的系统。整个项目将向外推进 有机结构与合成研究。

Rigid, polycyclic cage systems of high symmetry and strain are of special interest, both for the fundamental aspects of their chemistry and as sources of new and unusual kinds of materials not found in nature. Cubane, an example nonpareil, is now available sufficiently easily and in sufficient quantity to use the system as a practical starting material for the synthesis of other exceptional ring systems, e.g. azahomocubanone, dehydrocubane, azacubane, 1,1':3,3'-biscyclobutane, etc. These systems are important as probes into the effects of well-defined, but unusual molecular structure on bonding, reactivity, and other properties which will be evaluated in the course of this work. As such compounds and their derivatives are completely new ring systems of very novel type they present opportunities for the discovery of new pharmacologically valuable materials. Further, as the geometric requirements of the carbon framework of these systems are far from ordinary, tactical synthesis is an exceptional challenge. The work therefore will also result in the development of new ways for building and manipulating the skeletons of complex systems. The whole project will push outward the frontiers of organic structural and synthesis research.