Novel Microbial Pd Catalysts from Waste for Sustainable Synthesis

钯（Pd）是现代化学和制药工业中广泛使用的催化剂，由于全球需求和供应链压力的增加而供不应求。我们最近的研究表明，阿拉斯加脱硫弧菌可以用于从废物中回收Pd，以作为在节能制造条件下工作的纳米颗粒催化剂重新使用。来源于细菌的Pd催化剂显示出增强的化学性质，并且可以催化在制药工业中使用的小分子的形成。在这里，我们将（i）优化用于这种催化的纳米颗粒（ii）设计其重复使用和再制造的路线，以便Pd可以连续回收和重复使用，以及（iii）扩大细菌衍生Pd催化的反应组合，并证明与其他金属纳米颗粒的催化作用。这种新兴的生物技术为Pd的可持续利用铺平了道路，为改进Pd催化剂创造了新的循环途径，并取代了目前Pd催化剂使用的线性模式，这种模式产生了废物，是不可持续的，并且依赖于不安全的供应链。

Palladium (Pd) is a widely used catalyst in the modern chemical and pharmaceutical industries and is in short supply due to increasing global demand and supply chain pressures. Our recent studies have shown that the bacterium Desulfovibrio alaskensis can be used to recover Pd from waste for reuse as nanoparticle catalysts which work under energy-efficient manufacturing conditions. The Pd catalysts derived from the bacteria display enhanced chemical properties and can catalyze the formation of small molecules of use in the pharmaceutical industry. Here, we will (i) optimise the nanoparticles for this catalysis (ii) devise routes for their reuse and remanufacture so that the Pd can be continuously recovered and reused and (iii) expand the portfolio of reactions catalysed by the bacterially derived Pd and demonstrate catalysis with other metal nanoparticles. This emerging biotechnology paves the way for the sustainable use of Pd, creating new circular pathways to improved Pd catalysts and replacing the current linear model of Pd catalyst use, which creates waste, is unsustainable and reliant on insecure supply chains.