SYNTHESIS AND CHEMISTRY OF NEW POLYCYCLIC SYSTEMS

具有高对称性和高应变的刚性多环笼系统具有特殊的 兴趣，无论是对他们的化学基本方面， 自然界中没有的新的和不寻常的材料的来源。 古巴， 一个无与伦比的例子，现在已经足够容易地获得， 足够的量以使用该系统作为实际的起始材料， 其它特殊环系，例如氮杂高古巴酮， 脱氢立方烷、氮立方烷、1，1 '：3，3'-双环丁烷等。 重要的是作为探针的影响，定义明确，但不寻常的分子 结构对键合、反应性和其他性能的影响， 在这项工作中进行评估。 作为这样的化合物及其 衍生物是全新的环系统的非常新颖的类型，他们提出 发现新的可再生能源的机会 材料. 此外，由于碳框架的几何要求， 这些系统远非普通，战术综合是一个 特殊的挑战。 因此，这项工作还将导致 开发构建和操纵骨骼的新方法 复杂的系统 整个项目将推动 有机结构和合成研究。

Rigid, polycyclic cage systems of high symmetry and strain are of special interest, both for the fundamental aspects of their chemistry and as sources of new and unusual kinds of materials not found in nature. Cubane, an example nonpareil, is now available sufficiently easily and in sufficient quantity to use the system as a practical starting material for the synthesis of other exceptional ring systems, e.g. azahomocubanone, dehydrocubane, azacubane, 1,1':3,3'-biscyclobutane, etc. These systems are important as probes into the effects of well-defined, but unusual molecular structure on bonding, reactivity, and other properties which will be evaluated in the course of this work. As such compounds and their derivatives are completely new ring systems of very novel type they present opportunities for the discovery of new pharmacologically valuable materials. Further, as the geometric requirements of the carbon framework of these systems are far from ordinary, tactical synthesis is an exceptional challenge. The work therefore will also result in the development of new ways for building and manipulating the skeletons of complex systems. The whole project will push outward the frontiers of organic structural and synthesis research.