SYNTHESIS OF ANTIBIOTIC BRANCHED SUGARS

支链糖是糖的重要结构组分， 许多具有抗菌和抗肿瘤作用的天然物质 特性. 拟议研究的目的是 完成了霉卡糖，克拉定糖， Arcanose、axenose、pillarose、olivomycose、evermicose和 trioxacarcinose B，利用一种新的策略， 首先是四元立构中心的构建。 作为这项研究的一部分，α-酮酰胺的化学性质 二价阴离子（一种以前未知的碳酰亚胺物质）将是 完全定义。 预计这些信息将在 在未来的规划中具有重要的战略意义 生物重要化合物的全合成。 在仲烯丙基醇系统中的无环立体控制是 化学合成中的一个重要问题，最近 受到越来越多的关注。 中获得的结果 这项研究将有助于理解这一点。 在更构象模糊的叔烯丙基过程 系统.

Branched-chain sugars are improtant structural components of many natural substances posessing antibotic and antitumor properties. The objective of the proposed research is to accomplish the de novo chiral synthesis of mycarose, cladinose, arcanose, axenose, pillarose, olivomycose, evermicose, and trioxacarcinose B, utilizing a novel strategy which calls for the construction of the quaternary stereocenters first. As part of this investigation, the chemistry of a -ketoamide dianions (a previously unknown carbaninonic species) will be fully defined. It is anticipated that such information will be of general starategic importance in the planning of future total syntheses of biologically important compounds. Acyclic sterocontrol in secondary allylic alcolhol systems is an important problem in chemical synthesis, and has recently received increasing attention. Results obtained in the proposed research will contribute to the understanding of this process in the more conformationally ambiguous tertiary allylic systems.