Ageing Research Networks Global Partnering Awards UK, Singapore, and Australia

众所周知，衰老是多因素的，有许多生理和认知变化，会在一生中影响健康和生活质量。通常，对年龄相关变化的研究是由来自独立专业和学科的科学家进行的，例如皮肤/骨骼/肌肉/大脑等。因此，尽管在理解如何管理肌肉或皮肤的衰老衰退方面取得了进展，但这些话题被集中在一起是不寻常的--然而，这正是每个人都会发生的事情。我们的新联盟解决了这个问题。我们希望从整体上解决老龄化问题。由英国最好的老龄化研究网络以及相关的临床和行业合作伙伴组成的七个团体走到了一起，以建立更紧密的联系，并为志同道合的团体架起国际边界的桥梁。我们的网络发现，新加坡和澳大利亚的合作与我们的优先事项高度一致。我们的网络专业涵盖皮肤老化，介绍了皮肤微生物组的最新研究；肌肉衰退和如何建立韧性；营养的重要性及其与健康寿命的联系；年龄对细胞和细胞外基质代谢过程的影响；最后是细胞衰老。因此，这就是生物学。但除此之外，该联盟将解决几个影响健康老龄化的社会因素，如多样性(性别、种族)；不平等和剥夺；流动性，最后是社区。后者是至关重要的，因为许多老年人在护理环境中度过他们的最后几年。我们想知道如何预防或延缓脆弱和相关的生活质量下降，不仅是在英国，而且是从全球的角度。我们的财团将在哪里运作？在英国政府的支持下，我们将在英国和一些出色的国际合作伙伴之间建立更紧密的联系。例如，在新加坡，A*STAR是新加坡领先的公共部门机构，其研究小组进行跨学科的皮肤研究，与公共部门、医学界和行业合作，将研究转化为创新，以改善皮肤健康，对亚洲社区产生经济和社会影响。在澳大利亚，我们将与医学院和研究机构的几个小组合作，重点关注新陈代谢健康；健康新陈代谢的生物标记物；食物、饮食和健康老龄化，以及皮肤病和皮肤病。目前，各个网络已经与不同的群体建立了联系，但这些联系需要结合在一起，以便在其老龄化研究的关键领域实现建设性的合作。我们将如何通过网络实现效益？这笔资金将允许研究人员在几个场合会面，将老龄化研究学科聚集在一起--可能是第一次。我们将在英国、新加坡和澳大利亚安排具体的网络活动。这些将结成新的联盟，并导致可持续的研究计划，为所有公民创造老龄化解决方案。重要的是，我们将促进早期职业研究人员在老龄化研究方面建立具有国际视野的研究职业生涯，这将为这些年轻科学家带来在全球相关项目中共同工作的机会。总而言之，我们将建立一个新的社区，建立持久的合作和友谊，并通过共同努力加快老龄研究的进展。

Ageing is known to be multifactorial, with many physiological and cognitive changes that impact health and quality of life over the lifespan. Often research into age-related changes is carried out by scientists from independent specialties and disciplines such as skin/bone/muscle/brain etc. Thus, whilst advances in understanding how to manage the ageing decline of say, the musculature, or the skin, proceeds at a pace on its own, it is unusual that these topics are brought together - yet in each person, this is exactly what happens.Our new consortium solves this problem. We want to tackle ageing holistically. Seven groups comprising the UK's best ageing research networks, and associated clinical and industry partners, have come together to forge closer links with each other and to bridge international boundaries to like-minded groups. Our networks have identified that collaborations in Singapore and Australia are highly aligned to our priorities. Our network specialisms cover skin ageing, introducing the latest research in skin microbiome; muscle decline and how to build resilience; the importance of nutrition and how it links to healthy lifespan and the impact of age on metabolic processes in cells and the extracellular matrix; and lastly cellular senescence. So, that is the biology covered.However, in addition, this consortium will address several social factors that impact healthy ageing such as diversity (gender, ethnicity); inequality and deprivation; mobility and finally community. The latter is vitally important as many elderly people live their final years in care settings. We want to know how to prevent or delay frailty and associated decline in quality of life, not just in the UK, but with a Global perspective.Where will our consortium operate? With support from the UK Government, we will forge stronger links with each other in the UK, and some fantastic international partners. For example, in Singapore, research groups in A*STAR, which is Singapore's lead public sector agency, conduct interdisciplinary skin research, collaborating with the public sector, the medical community and industry to translate research into innovations for improved skin health with economic and societal impact in the Asian communities. In Australia, we will work with several groups across medical schools and research institutions, focusing on metabolic health; biomarkers for healthy metabolism; food, diet and healthy ageing and dermatology and skin disease that increase with frailty. Currently, the individual networks have existing links to disparate groups, but these need to be brought together to achieve constructive collaboration in their key areas of ageing research.How will we go about achieving benefits through the network? The funding will allow researchers to meet all together on several occasions, bringing ageing research disciplines together - possibly for the first time. We will arrange specific networking events in the UK, Singapore, and Australia. These will forge new alliances and lead to sustainable research programmes that will create ageing solutions for all citizens. Importantly, we will facilitate early career researchers to establish research careers in ageing research with an international dimension, that will bring these young scientists the opportunities to work together in globally relevant projects. In summary we will forge a new community, build lasting collaborations and friendships, and speed up the advances in ageing research by working together.