PHOSPHOINOSITIDE & INOSITOL PHOSPHATE ANALOG SYNTHESIS

肌醇磷脂和肌醇磷酸盐已经被密集地 近年来关于它们在细胞内的作用的研究 响应细胞外刺激的信号传递和提供钙 放手。已经为这一活动假定的机制 涉及磷脂酰肌醇和磷脂酰肌醇的磷酸酯键的断裂 肌醇磷酸盐。在目前的工作中，假设等位元 它们的亚甲基和羟亚甲基膦酸类似物 合成磷酸盐作为新陈代谢过程的探针和AS 信号传递过程的潜在监管者。这些膦酸， 不能进行正常的水解程序，但保持 同样大小和形状的天然材料，预计能够 参与一些正常的新陈代谢过程，但扰乱 需要磷酸酯裂解的信号传递过程。

The phosphoinositides and inositol phosphates have been intensively investigated in recent years regarding their role for intracellular signalling in response to extracellular stimuli and providing calcium release. The mechanisms which have been postulated for this activity involve cleavage of phosphate ester linkages of the phosphoinositides and inositol phosphates. In the present work it is postulated that isosteric methylene and hydroxymethylene phosphonic acid analogues of these phosphates be synthesized as probes of the metabolic processes and as potential regulators of the signalling process. The phosphonic acids, unable to undergo the normal hydrolytic procedures, yet maintaining the same size and shape of the natural materials, are anticipated to be able to participate in some of the normal metabolic processes, but to perturb the signalling process which requires phosphate ester cleavage.