PROSPEcT: Ecotoxicology test protocols for representative nanomaterials in support of the OECD sponsorship programme

拟议的研究是展望链接项目的组成部分，该项目是通过“从工程到应用的纳米科学”方案启动的。该项目旨在为经合组织制造纳米材料工作组(WPMN)所述的纳米材料全球安全评估作出直接贡献。LINK项目将开发两种商定的纳米材料的基本和开创性测试方法和数据，这两种材料对英国具有特别的商业意义。该项目将创新科学基础，以适应或创造能够对纳米材料进行生态毒理危害评估的测试方法。这两种粒子(即CeO2和ZnO)都是14种纳米材料清单的一部分，这些材料被确定为与纳米技术的全球经济影响具有商业相关性。此外，结合OECD测试计划中其他纳米材料的并行和协调开发，开发表征CeO2和ZnO纳米材料的方法将使未来能够建立QSAR(定量结构活性关系)，用于预测新型纳米材料的安全性。由此产生的科学进步将有助于确保英国纳米技术商业化的经济未来，并为OECD的全球纳米材料安全评估计划提供关键的英国领导和信息。

The proposed research forms an integral part of the PROSPEcT LINK project, initiated through the 'Nanoscience through Engineering to Application' programme. The project aims to provide a direct contribution to the global safety assessment of nanomaterials described by the OECD Working Party on Manufactured Nanomaterials (WPMN). The LINK project will develop essential and seminal test methods and data on two agreed nanomaterials that are of particular commercial relevance to the UK. The project will innovate the scientific foundations for adapting or creating test methods that enable the ecotoxicological hazard assessment of nanomaterials. Both particles (i.e. CeO2 and ZnO) are part of a list of 14 nanomaterials, identified as commercially relevant to the global economic impact of nanotechnology. Furthermore, the development of methods to characterize CeO2 and ZnO nanomaterials in concert with parallel and coordinated development for other nanomaterials across the OECD testing program will enablethe future establishment of QSARs (Quantitative Structure Activity Relationships) for predictive safety evaluations of novel nanomaterials.The resulting scientific advancement will help to secure an economic future for the commercialisation of nanotechnologies in and by the UK and provide crucial UK leadership and information to the OECD's global programme on nanomaterials safety assessment.