OSCILLATORY PATTERNS OF BREATHING AND HEART RATE IN SIDS

我们的目标是确定对振荡模式的分析是否 呼吸和心率可以确定婴儿有可能死于 婴儿猝死综合症，简称SIDS。因为振荡模式是 呼吸暂停和呼吸不足事件，分析这些模式，而不是 呼吸暂停次数或时间呼吸暂停百分比的表格，可以识别 与小岛屿发展中国家相关的异常。周期性呼吸，有时用作 一个危险因素，只是呼吸机振荡的一种形式。我们的分析 涵盖了广泛的振荡现象，我们确定了许多 图案的特征，以及它们出现的频率。 来自小岛屿发展中国家受害者和配对对照的数据将由David博士提供 索索尔，伦敦心胸研究所，将从他的 9,251名婴儿(29名)呼吸和心率的前瞻性记录 其中有几个人死于小岛屿发展中国家。在这些24小时的记录中，呼吸信号， 从一个贴在腹部的压力胶囊，类似于气体描记 从胸壁的电阻抗获得的记录。虽然 初步研究表明，作为平均通风的衡量标准是不准确的 这种类型的记录可以准确地在 通风，特别是强、低频率的模式，如 预计与小岛屿发展中国家的高风险相关。混杂的存在 而阻塞性呼吸暂停不能从这些录音中确定。 然而，伴随这种呼吸暂停的振荡模式仍然可能是 已确认身份。 对正常特征和异常特征的评估将基于 呼吸暂停是否与呼吸模式有关，而不是与 特发性，与呼吸模式相关的呼吸暂停是否 在适当的持续时间内，图案特征是否包括 模式的发生率、周期时间和强度是正常的，并且 心率的模式是否与呼吸的模式相关， 重点研究了它们之间的相位和幅度关系 模式。这些区域中的任何一个或所有区域的异常可能表明 增加了小岛屿发展中国家的风险。 识别小岛屿发展中国家的风险是重要的，这两个步骤 了解小岛屿发展中国家的原因，以便可以尝试预防 “高危”人群。

Our goal is to determine whether analysis of oscillatory patterns in respiration and heart rate can identify infants at risk to die of the Sudden Infant Death Syndrome, SIDS. Because oscillatory patterns underlie apnea and hypoventilatory events, analysis of these patterns, rather than tabulation of numbers of apneas or percent time apneic, may identify abnormalities associated with SIDS. Periodic breathing, sometimes used as a risk factor, is only one form of ventilatory oscillation. Our analysis covers a wide range of oscillatory phenomena and we determine many characteristics of the patterns, in addition to how often they are present. Data from SIDS victims and matched controls will be provided by Dr. David Southall, Cardiothoracic Institute, London, and will be drawn from his prospective recordings of respiration and heart rate on 9,251 infants, 29 of whom died of SIDS. In these 24-hour recordings, the respiration signal, from a pressure capsule taped to the abdomen, is similar to pneumogram recordings obtained from electrical impedance of the chest wall. Although inaccurate as a measure of mean ventilation, preliminary studies indicate that this type of recording can accurately convey oscillatory patterns in ventilation, particularly strong, low frequency patterns such as those expected to be correlated with high risk for SIDS. The presence of mixed and obstructive apneas cannot be determined from these recordings. However, oscillatory patterns which accompany such apneas can still be identified. Assessment of normal versus abnormal characteristics will be based on whether apneas are related to breathing patterns as opposed to being idiopathic, whether the apneas which are related to breathing patterns are of an appropriate duration, whether pattern characteristics including the incidence, cycle time, and strength of the patterns, are normal, and whether patterns in heart rate are associated with patterns in respiration, with emphasis on the phase and amplitude relationships between these patterns. Abnormality in any or all of these areas may be indicative of increased risk for SIDS. Identification of risk for SIDS is important both as a step toward understanding the cause of SIDS and so that prophylaxis can be attempted on the "at risk" population.