COMPUTER SIMULATION STUDIES OF THE MENSTRUAL CYCLE

对月经周期的体内研究表明， 挑战，因为他们处理的是一个复杂的实体， 大量变量之间的多重相互作用，而不是 所有这些都可以在体内环境中同时控制。 体内研究的辅助或替代方法 已经提出了人类生殖周期，其中包括 计算机模拟方法。 本研究提案 这是一种尝试，以评估这种方法的有效性。 研究人员建议用计算机继续他们的研究 周期性形态和内分泌变化的模型， 描述月经周期。 该提案包含三个实际目标。 第一个目标是 完善原有的月经周期计算机模拟模型。 这个模型是在十多年前开发的;新的数据和 现在必须对概念进行评估、测试，并在必要时， 整合到模型中。 第二个目标是发展一个 复杂的用户界面。 该模型将适用于PC 台式计算机硬件，并将纳入原则， 所谓的“专家系统”程序。 这将允许 生理学家测试和使用计算机模型在一个高度 复杂，但易于控制的时尚，而不需要 广泛的计算机背景。 第三个目标是测试 这种计算机建模方法在实验中的实用性 设置. 选定的实验者将为我们提供一个 实验设置。 经过挑选的实验者将为我们提供 通过他们的日志记录能力对模型进行客观分析 模拟结果 最终，一个经过完善和验证的模型， 月经周期可用于辅助两种实验 设计和结果解释，从而提高知识 从体内实验中获得。

In-vivo studies of the menstrual cycle present enormous challenges, as they deal with a complex entity which is the result of multiple interactions between a large number of variables, not all of which can be controlled at one time in an in-vivo setting. Adjunct or alternative approaches to the in-vivo study of the human reproductive cycle have been suggested, among which is the computer simulation approach. This research proposal represents an attempt to evaluate the validity of this approach. The investigators propose to resume their studies with a computer model of the cyclic morphological and endocrine changes which characterize the menstrual cycle. The proposal contains three practical aims. The first aim is to refine the original menstrual cycle computer simulation model. This model was developed more than a decade ago; new data and concepts must now be evaluated, tested and, where required, integrated into the model. The second aim is to develop a sophisticated user interface. The model will be adapted to PC desktop type computer hardware and will incorporate principles of what are called "expert system" programs. This will allow physiologists to test and use the computer model in a highly sophisticated, yet easily controllable fashion without the need for an extensive computer background. The third aim is to test the utility of this computer modeling approach in an experimental setting. Selected experimentalists will provide us with an experimental setting. Selected experimentalists will provide us with an objective analysis of the model through their ability to log simulation results. Ultimately, a refined and validated model of the menstrual cycle can be used to assist in both experimental design and result interpretation and thereby enhance knowledge gained from in-vivo experimentation.