NEUROPATHOLOGY AND BRAIN DEVELOPMENT IN PEDIATRIC AIDS

人类免疫缺陷病毒(HIV)除了对 免疫系统已经被证明能够产生初级的和持久的 无情感染中枢神经系统(CNC) 进行性脑病。这种感染的后遗症是 在儿科年龄组中尤其具有破坏性。中国的艾滋病毒感染情况 婴儿和儿童会导致小头畸形和脑萎缩。 儿童艾滋病中的机会性中枢神经系统感染是罕见的。其作用机制 中枢神经系统的细胞损伤和细胞数量，主要是 被艾滋病毒破坏的人仍然不清楚。这项研究的目的是 明确艾滋病毒感染对已开发人群和发展中人群的影响 脑；确定中枢神经系统萎缩/小头畸形的程度；并确定 哪些脑细胞群在儿童艾滋病中受到影响。大脑 从感染艾滋病毒的婴儿和儿童的身体解剖中获得的 无论是在子宫内，还是在出生后通过输血或用血 产品，以及来自非艾滋病年龄匹配对照病例的大脑 进行了神经病理学评估。组织学、体视学、形态计量学 并将使用免疫细胞化学方法。从这里得到的信息 研究将有助于更好地了解艾滋病毒的影响 对发育中的人脑的感染和更好的临床 儿童艾滋病中HIV脑病的病理学定义。

Human Immunodeficiency Virus (HIV) in addition to its profound effect on the immune system has been shown to produce a primary and persistent infection of the Central Nervous System (CNC) with relentlessly progressive encephalopathy. The sequelae of this infection are particularly devastating in the pediatric age group. HIV infection in infants and children leads to microcephaly and brain atrophy. Opportunistic CNS infections in pediatric AIDS are rare. The mechanisms of cellular damage and the cell population in the CNS which is primarily damaged by HIV are still not known. The objective of this study is to define the effect of HIV infection on a developed and on a developing brain; to define the extent of CNS atrophy/microcephaly; and to determine which brain cell populations are affected in pediatric AIDS. Brains obtained at autopsy from infants and children with AIDS infected with HIV either in utero, or postnatally by blood transfusion or with blood products, and the brains from non-AIDS age-matched control cases will be evaluated neuropathologically. Histological, stereological, morphometric and immunocytochemical methods will be used. The information from this study will contribute to a better understanding of the effect of HIV infection of the developing human brain and for better clinico- pathological definition of HIV encephalopathy in pediatric AIDS.