Surface Engineered Biomaterials to Control Inflammation

该项目的总体目标是提供表面纳米形貌如何影响炎症反应的机械性理解。实验证据表明，工程化表面纳米拓扑术与表面化学相结合，下调了原代巨噬细胞的促炎细胞因子的表达。这些发现的意义在于，有可能以一种方式设计生物医学设备表面的纳米拓扑术，从而导致所需的和可预测的炎症水平和随后的异物反应(FBR)医疗植入物和组织工程构造。

The overarching aim of this project is to provide a mechanistic understanding of how surface nanotopography affects inflammatory responses. Experimental evidence demonstrates that engineered surface nanotopography in combination with surface chemistry downregulates the expression of proinflammatory cytokines from primary macrophages. The significance of these findings is that it may be possible to engineer the nanotopography of a biomedical device surface in a manner which leads to a desired and predictable level of inflammation and subsequent foreign body reaction (FBR) medical implants and tissue engineering constructs.