ORGANIZING THE HGI--SOCIAL IMPACT AND TECHNOLOGY DESIGN

描述（研究者摘要）：绘制和测序的倡议 人类基因组正进入一个关键时期。 在接下来的五年里， 基因组学社区将专注于开发技术， 实现其目标的组织结构 到2005年完成序列。 20世纪90年代初做出的选择 将确定测绘技术体系的基本轮廓， 对人类基因组进行测序，并为二十一世纪奠定新的基础。 世纪生物学和生物技术。 设计的社会影响， 基因组计划的实施可能是巨大的。 决定 今天提出的关于技术和组织结构的 基因组计划将影响该计划产生的信息是如何 以及这些信息的社会影响。 同样地， 关于如何管理科学中固有的紧张关系的决定， 这种规模的合作可能会对研究伦理产生影响 远远超出了基因组学界。 因此，未来五年是一个 战略研究机会对理解 基因组计划的发展及其影响。 拟定研究 将探讨如何议程的研究，组织设计， 因为基因组学界的政策是在这一关键时期形成的， 期 技术的系统/网络方法，以及 论文的设置，提供了一个理论框架。 该研究将使用 前瞻性，纵向研究的一个队列的关键线人从 社区，深入访谈，并仔细参与观察 选择实验室

DESCRIPTION (Investigator's Abstract): The initiative to map and sequence the human genome is entering a critical period. For the next five years, the genomics community will focus on developing technology and organizational structures for accomplishing its goal of obtaining the complete sequence by the year 2005. The choices made in the early 1990s will define the basic outline of the technological system for mapping and sequencing the human genome and lay a new groundwork for twenty first century biology and biotechnology. The social impacts of the design and implementation of the genome project are likely to be enormous. Decisions made today about the technological and organizational structure of the genome project will affect how the information the project produces is eventually used and the social impact of that information. Similarly, decisions about how to manage the tensions inherent in scientific collaboration on this scale are likely to have an effect on research ethics well beyond the genomics community. The next five years are thus a strategic research opportunity of exceptional importance for understanding the evolution of the genome project and its impact. The proposed study will explore how the agenda for research, for organizational design, and for policy of the genomics community takes shape during this critical period. The system/network approach to technology, and the concept of agenda-setting, provide a theoretical framework. The research will use a prospective, longitudinal study of a cohort of key informants from the community, in-depth interviewing, and participant observation in carefully selected laboratories.