FACTORS AFFECTING DISTRIBUTION OF MYOCARDIUM FLOW

这项建议是继续进行旨在阐明多种因素的研究， 其控制心肌灌注和功能。 虽然这项工作不会 在人类受试者中进行，每项拟议的研究旨在 回答定义生理学或病理生理学的重要问题 健康和疾病期间的心脏功能。 为此，无论何时 可能的话，在清醒的动物中进行研究;动物模型模拟 使用人心血管疾病。 研究报告包含六个 一般类别：1.冠状动脉血管对短暂扰动的反应。 2.心肌血流量与机械性能的相互作用 左心室 3.嘌呤代谢在心肌缺血中的作用 短暂缺血后的功能。 4.抵押品的发展和作用 狗和猪 5.肥厚心室的心肌血流量。 6. 肥厚心室的心肌力学。

This proposal is to continue studies designed to elucidate the multiple factors which control myocardial perfusion and function. Although the work will not be carried out in human subjects, each of the proposed studies is designed to answer questions of importance in defining the physiology or pathophysiology of cardiac function in man during health and disease. To this end, whenever possible, studies are carried out in awake animals; animal models simulating human cardiovascular disease are employed. The research proposal contains six general categories: 1. Response of coronary vasculature to brief perturbations. 2. Interaction between myocardial blood flow and mechanical properties of the left ventricle. 3. The role of purine metabolism in determining myocardial function following brief ischemia. 4. Collateral development and function in dogs and pigs. 5. Myocardial blood flow in the hypertrophied ventricle. 6. Myocardial mechanics in the hypertrophied ventricle.