DYNAMIC RADIOGRAPHIC ASSESSMENT OF MYOCARDIAL FUNCTION

在过去的三年半里，一种新的非侵入性技术， 测量由于心肌梗死引起的心室功能障碍， 米尔顿S. 好时医疗中心 这项技术是基于对 二次辐射场，可用于精确测量的形状 心脏表面，并持续监测该形状的变化 在整个心动周期中。 目前的努力，旨在利用这一点， 精确表征时间依赖性心外膜的新技术 运动模式，并将这些正常运动模式与 从心肌梗死的闭胸模型中获得， 证明了基本的动态射线照相技术具有 有可能发展成为多方面的诊断模式。 的 所提出的动态射线照相技术的进一步发展 这里，如果成功，将导致成像系统能够：a） 测量并显示精确的三维运动模式，B） 使用非放射性示踪剂监测心肌灌注模式，c） 在线实时监测动态壁厚; d）测量 心输出量和射血分数。 这些能力将是 可能采用非侵入性的程序（非常低的辐射剂量）， 价格便宜，并且可以在门诊的基础上获得。 这里提出的研究的最重要的具体目标是 动态射线照相三维实时显示的持续发展 能力，发展能量分散的内循环运动， 动态壁厚测量能力，并开发了一种 测量心肌灌注模式的能力， 非放射性示踪剂

During the past three and one-half years, a new non-invasive technique for measuring ventricular dysfunction due to myocardial infarction and ischemia, dynamic radiography (DRG) has been developed at The Milton S. Hershey Medical Center. This technique, based upon the analysis of secondary radiation fields, can be used to precisely measure the shape of the cardiac surface and to continuously monitor the change in this shape throughout the cardiac cycle. Current efforts, directed toward using this new technology in the precise characterization of time dependent epicardial motion patterns and comparison of these normal motion patterns with those obtained from close-chest models of myocardial infarction, have demonstrated that the basic dynamic radiographic technique has the potential to be developed into multifaceted diagnostic modality. The further development of the dynamic radiographic technology as proposed here, if successful, will result in an imaging system capable of a) measuring and displaying precise three dimensional motion patterns, b) monitoring myocardial perfusion patterns using a non-radioactive tracer, c) monitoring on-line real-time dynamic wall thickness, and d) measuring cardiac output and ejection fractions. These capabilities would be possible with a procedure that is non-invasive (very low radiation dose), inexpensive, and available on an out-patient basis. The most important of the specific goals of the research proposed here is the continued development of the dynamic radiographic 3-D real-time display capabilities, the development of an energy dispersal endocardial motion and dynamic wall thickness measurement capability, and the development of a capability for the measurement of myocardial perfusion patterns using a non-radioactive tracer.