CARDIAC ADENOSINE RECEPTORS

这个项目测试了一些假设的预测， 是冠状动脉流量和心脏性能的生理调节剂。 这些包括嘌呤偶极矩和 环外嘌呤取代基与 冠状动脉腺苷受体的特殊区域决定了 腺苷的血管活性和茶碱的拮抗作用。 这些研究 使用C2和C6取代的nebularine和N1和N3烷基黄嘌呤。 腺苷的抗-N-g+构象体结合 该受体使用2个脚取代的2个脚脱氧腺苷。 研究 测试的假设，有地区差异的类型， 腺苷R受体利用酶促分散的心肌细胞， 与葡聚糖共价连接的腺苷类似物， 细胞

This project tests a number of predictions of the hypothesis that adenosine is a physiological regulator of coronary flow and cardiac performance. These include the predictions that the purine dipole moment and the stereoselective interaction of exocyclic purine substituents with specialized regions of the coronary adenosine receptor determine the vasoactivity of adenosines and antagonism by theophyllines. These studies employ C2 and C6 substituted nebularines and N1 and N3 alkylxanthines. Tests of the hypothesis that the anti-N-g+ conformer of adenosine binds to the receptor employs 2 feet-substituted 2 feet-deoxyadenosines. Studies testing the hypothesis that there are regional differences in the type of adenosine R receptors employ enzymatically dispersed cardiocytes and adenosine analogs covalently linked to dextrans to prevent penetration into cells.